Howorth Containment Solutions for the Pharmaceutical Sector

Howorth uses air engineering to create safe and clean working environments for pharmaceutical organisations.

Infection control solutions for the pharmaceutical industry

Howorth provides containment and infection control solutions to small businesses, blue-chip private companies and the government sector.

The company offers a prototyping service and a full-size mockup for operational ergonomic assessment before the final product is manufactured.

Howorth’s containment solutions and associated documentation meet the relevant European Commission (EC), good manufacturing practices (GMP), US Food and Drug Administration (FDA), International Organisation for Standardisation (ISO) and other global standards.

The company’s ISO 9001:2008 standard processes adhere to good engineering practices, internal design review specifications, quality control and traceability.

Downflow containment booths

Containment by airflow is a proven concept improved by Howorth.

Howorth’s booths use a unidirectional flow of air, which passes through ceiling mounted distribution screens to ensure contaminants are carried away from operators and into low-level exhaust grilles.

Recirculatory booths are used for powder operations and once-through booths are ideal for solvent or fume vapours.

Engineers will work with clients to develop an airflow containment solution that meets specific requirements. The booths provide enhanced levels of operator protection and are customisable to meet specifications.

Booths are flexibly designed and available in various construction materials, including 304/316L stainless-steel and epoxy coated carbon steel.

Howorth specialises in cooling coils and other climatic systems, as well as a wide range of ancillary equipment, including ventilated workbenches, integrated manipulators and drum handling systems.

The company’s designs are suitable for use in explosive environments.

High-containment screens

Howorth produces high-containment screens (HCS) to enhance the capabilities of any downflow booth, such as operations where an air suit or isolator is used.

Howorth’s 5D HCS is a flexible screen that offers four degrees of movement from side-to-side, front-to-back, or up and down with controlled rotation.

Developed in collaboration with existing booth operators, 5D HCS provides unparalleled levels of operator flexibility, making it the ideal solution for a wide range of processes.

The company’s range of screens can be easily integrated within existing booth facilities.

Howorth performs site surveys, design, manufacture, installation, commissioning, as well as site acceptance testing and validation services.

Process equipment for barrier isolator systems

Howorth designs and manufactures isolators that combine containment levels of less than 1μg/m3 with ergonomic and maintenance efficiency.

The company focuses on the interface between the operator and the client’s processes to ensure all production and containment levels are fully achieved.

A full-scale model can be produced that addresses ergonomic aspects and optimum placement of ancillary and process equipment. Modifications can be made before manufacturing.

Howorth integrates process equipment within barrier isolation systems and has worked on various projects with end users and original equipment manufacturers (OEMs).

Isolator applications include:

  • Dispensing and sub-division
  • Sampling and solids charging
  • Pack-off and heel recovery
  • Chemical synthesis
  • Mills
  • Fluid beds and granulators
  • Filter dryers

Pack-off heads for boxes and intermediate bulk containers

Howorth’s pack-off heads are compatible with a range of drums, kegs, bags, boxes and intermediate bulk containers (IBCs).

Pack-off head sealing configurations are available, including outward, downward and inward inflating. The company offer secondary pack-off containment products in the form of booths and isolators.

By using a secondary containment solution, protection can be improved and containment levels of less than 1μg/m3 can be achieved.

Kilo labs and glassware enclosures

Howorth produces modular enclosures with either a horizontal or a vertical system, depending on the application. Localised flow can be provided inside and outside the enclosure for added protection during the loading process.

Solvent and liquid drum booths

Drum booths are designed to provide low parts per million (ppm) containment during solvent or liquid transfer and other handling processes. These include drum-to-drum transfer or drum-to-process reaction vessel.

Booths are available in different materials, including stainless-steel or polypropylene for added corrosion-resistance.

Howorth focuses on simplifying installation and commissioning procedures. The company provides extensive documentation, ergonomic models and factory acceptance tests (FATs) ensure that site acceptance testing (SAT) is trouble-free.

As an OEM supplier, Howorth ensures that client equipment remains in peak condition through the supply of quality approved parts. Experienced service engineers maintain, validate and, if required, upgrade equipment.

About Howorth

Through its acquisition of leading UK filtration company Westbury Filtermation, Howorth offers a range of filter products designed for use in containment systems.

Solutions include pre-filters, high efficiency filters, HEPA and ULPA products that are engineered to meet specific requirements of containment systems.

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Press Release

Contracting Sterility Testing to a GMP Certified Laboratory

Sterility testing of pharmaceutical products is a mandatory requirement when bringing a drug to market and assessing longer term safety. There are various options for manufacturers to facilitate this process. The most convenient way is to contract out to a good manufacturing practice (GMP) certified laboratory.

White Papers

Howorth’s 5D High-Containment Screen

Howorth's high-containment screens (HCS) are a simple and effective way of boosting containment capabilities of any downflow booth.

Address
Howorth

Lorne Street, Farnworth

Bolton

BL4 7LZ

Manchester

United Kingdom

+44 1204 571131 +44 1204 862378 www.howorthgroup.com

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Press Release

15 August 2017

Sterility testing of pharmaceutical products is a mandatory requirement when bringing a drug to market and assessing longer term safety. There are various options for manufacturers to facilitate this process. The most convenient way is to contract out to a good manufacturing practice (GMP) certified laboratory.

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24 April 2017

Howorth has announced it will be attending Making Pharmaceuticals in Coventry.

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21 October 2016

Howorth Air Technology provides a fully validated bio-decontamination system, which helps reduce spread of healthcare-associated infections (HAI) for application in safety cabinets to hospital operating theatres.

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9 August 2016

Innovative technology is a key factor to consider when improving the operating theatre environment.

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Regional Offices

Howorth

Lorne Street, Farnworth

Bolton

BL4 7LZ

Manchester

United Kingdom

+44 1204 571131 +44 1204 862378 www.howorthgroup.com

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