Croda - High Purity Pharmaceutical Excipients and Lipid Actives

Croda Health Care is a leading supplier of naturally derived, high quality excipients and lipid actives for pharmaceutical, nutritional and animal health markets. Croda focuses on delivering condition and application-specific solutions to meet the stringent technical, quality and market requirements of these industries. Our technical expertise includes the fields of drug delivery, dermatology, wound healing, disease management and veterinary excipients.

DRUG DELIVERY EXCIPIENTS

The right excipient can maximise the solubility, stability and efficacy of APIs. Croda's GMP excipients include:

• Ultra high purity fatty acids and esters
• Pharmaceutical emulsifiers and solubilisers
• Glycerol mono and di fatty acid esters
• Macrogol ethers
• Macrogol esters
• Macrogol glycerol esters
• Polysorbates
• Self-emulsifying waxes
• Sorbitan esters
• Pharmaceutical lanolin and derivatives
• Super refined vegetable oils

Ingredients for parenteral, oral and topical drug delivery systems have been optimised to increase drug bioavailability and boost formulation efficacy. Croda's high purity PEG-400 NF, for example, is designed specifically for pharmaceutical use and ensures effective delivery of actives by minimising drug interaction with the excipient.

DERMATOLOGY AND WOUND HEALING

Croda's pioneering ingredients that enhance the efficacy and feel of topical pharmaceuticals include emollients, emulsifiers and lipid actives for skin moisturisation, barrier repair and wound healing. Dermatological applications include emollient therapy and wound healing where recent clinical studies have demonstrated the therapeutic benefits of our world-leading medical grade lanolins. Further research has proven the value of our Crossential novel plant lipids for the treatment of common inflammatory skin conditions, such as eczema and psoriasis.

Key products include:

• Pharmaceutical lanolin and derivatives
• Medilan™ wound healing excipients
• Crossential omega-3 and -6 fatty acids
• Pharmaceutical emulsifiers and solubilisers
• Crodamol fatty acid esters

HIGH PURITY OMEGA-3 AND OMEGA-6 FATTY ACID CONCENTRATES

Croda is a leading supplier of high purity omega-3 and omega-6 fatty acid concentrates, providing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and gamma-linolenic acid (GLA) at up to 95% purity. These vital lipids are recommended for the management of specific medical conditions e.g. heart disease, rheumatoid arthritis, mood disorders and inflammatory skin conditions.

Key products include:

• Incromega omega-3 fatty acids
• Crossential omega-6 fatty acids

VETERINARY EXCIPIENTS - LIPID VEHICLES, PHARMACEUTICAL SURFACTANTS, SOLUBILISERS AND EMULSIFIERS

Croda's veterinary excipients include pharmaceutical surfactants, solubilisers, emulsifiers and lipid vehicles that can be used to enhance the delivery and efficacy of actives in many types of animal health products. Our high purity super refined oils and fatty acid esters have been shown to boost formulation efficacy by reducing drug interaction with the carrier. Application areas cover topical (pour-ons, ointment bases) and parenteral dosage forms (injectables) and nutritional additives.

Key products include:

• Super refined vegetable oils
• Crodamol fatty acid esters
• Pharmaceutical emulsifiers and solubilisers

Croda is a key marketing division of Croda International plc, the UK-based manufacturer of speciality ingredients for the global consumer and health care markets. Manufacturing facilities and expertise include:

• GMP API supercritical technologies - allows separation, concentration - purification of target compounds to 95%+
• GMP API ethoxylation - ultra high purity ethoxylates for pharmaceutical applications
• Super refining - proprietary lipid purification technique to improve drug stability
• QA systems comply with ICH Q7a