Roquette Pharma Global Supplier of Pharmaceutical Excipients and Actives

Raw materials, excipients, and actives

Roquette is a long-established supplier of raw materials, excipients, and actives to the pharmaceutical and cosmetic industries, which also benefit from its valuable services.

Oral dosage forms are still the most commonly-used formulations, generating a complex list of manufacturing, regulatory, and consumer-related issues. Among Roquette’s trusted excipients and services, there are some particularly suitable solutions for dilution, direct compression, filling, disintegration, encapsulation, and film-forming coating.

Diluents for moisture-sensitive formulation

Mannitol has some of the most desirable of excipient profile qualities, making it one of the most suitable diluents for moisture-sensitive formulation, coupled with a pleasant taste.

Roquette has been working continuously on improving these remarkable intrinsic properties, creating an exceptional mannitol PEARLITOL® range, including PEARLITOL® C, PEARLITOL® SD, PEARLITOL® DC, and PEARLITOL® PF.

Direct compression solutions

Mannitol PEARLITOL® SD and DC are widely used and particularly adapted to direct compression. High-quality chewable, orodispersible or suckable tablets, with a pleasant taste and texture, can also be formulated and produced very easily with new directly compressible polyols such as PEARLITOL® Flash (a new mannitol compound dedicated to ODT), SweetPearl® P 300 DC (DC maltitol), XYLISORB® 100 DC & 200 DC (DC xylitol) and NEOSORB® P 150 DC and P 300 DC (DC sorbitol).

Other excipients are also part of Roquette Pharma direct compression solutions:

  • STARLAC®, a co-processed starch / lactose excipient, gives excellent direct compressibility with fast disintegration
  • LYCATAB® C, a partially pregelatinised starch acting as a filler, binder disintegrant
  • LYCATAB® Mineral, a starch / calcium carbonate compound developed as a direct compression ingredient mainly for nutraceutical calcium supplementation

To help you in your scaling-up process, Roquette also provides a new compression simulation service.

Super-disintegrants for different formulation needs

Roquette’s pioneering GLYCOLYS® sodium carboxymethyl starch has for decades set the reference standard for the super-disintegration function in solid dosage forms. The company has developed different grades offering, for instance, particular viscosity and pH.

Taste masking and encapsulation of apolar molecules

The unique composition of KLEPTOSE® LINECAPS (a short-chain amylose ingredient) is ideal for taste masking and encapsulation of apolar molecules in many dosage forms (liquids, chewable tablets, ODT, suspension, etc.). It is particularly suited to the paediatric and nutraceuticals markets.

Universal tablet coating solution

LYCOAT® film coating polymer and ReadiLYCOAT® ready-to-use coating systems allow tablets to be coated very quickly and to a high standard. Moreover, LYCOAT® film coating polymer delivers exceptional inertness where other coating polymers fail. Roquette offers on-site assistance for your trials, process parameters optimisation, etc.

Oral dosage forms for paediatric formulations

Oral dosage forms play an important role in primary care, in particular for paediatric formulations.

LYCASIN® is a maltitol syrup with properties ideal for the preparation of sugar-free syrups, lozenges and jellies, being widely used for confectionery applications. In the pharmaceutical industry, LYCASIN® is also a sucrose replacement in preparations suitable for diabetics.

Pryogen-free parenteral preparations

Parenteral preparations are essential life-saving drugs requiring reliable pyrogen-free ingredients.

Thanks to the intimate knowledge of its customer’s needs, Roquette is a trusted leader in the parenteral preparations market. It offers a reliable, pyrogen-free range of products, including pyrogen-free dextrose monohydrate LYCADEX® PF (for which it has launched a brand new dedicated production plant); mannitol PEARLITOL® PF; sorbitol NEOSORB® PF; and parenteral-grade hydroxypropyl betacyclodextrin KLEPTOSE® HPB/HP.

Check our website to discover the other products and services also available from Roquette Pharma.

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Press Release

Roquette to Attend AAPS Annual Meeting and Exposition in Denver, CO

Roquette has announced that it will be attending the AAPS Annual Meeting and Exposition in Denver, showcasing its latest scientific solutions in plant-based pharmaceutical ingredients (API).

White Papers

Taste Masking Acetaminophen Chewable Tablets Using Maltitol Plus Intense Sweetener Synergy

Use of technologies to mask the bitterness of active pharmaceutical ingredients (API) is limited in paediatric formulations by a lack of safety data covering children, in comparison to adults.

Address
Roquette Pharma

Pharmaceutical & Cosmetics Business Unit

62080 LESTREM Cedex

Other

France

+33 3 21 63 36 00 +33 3 21 63 94 64 PEARLITOL® FLASH self-disintegrating filler www.roquette-pharma.com Taste-Masking Solutions DC Solutions

Roquette Pharma Images

White Papers

Parenteral Preparations, Challenges in Formulations

Parenteral preparations are solutions, suspensions, emulsions for injection or infusion, powders for injection for infusion, and gels for injection and implants intended to be administered into the systemic circulation in humans or animals.

28 October 2016

Taste Masking Acetaminophen Chewable Tablets Using Maltitol Plus Intense Sweetener Synergy

Use of technologies to mask the bitterness of active pharmaceutical ingredients (API) is limited in paediatric formulations by a lack of safety data covering children, in comparison to adults.

13 September 2016

B-Cyclodextrins as a Solubilisation Tool for Insoluble APIs

One of the main challenges in drug delivery is to guarantee bioavailability of active ingredients, especially when they are poorly soluble and/or with a limited gastrointestinal permeability.

3 August 2015

Development of a Coated ODT Nutraceutical Formulation

Orally disintegrating tablets (ODTs) are getting more interesting delivery systems for the administration of active ingredients in the field of pharmaceuticals and nutraceuticals.

7 May 2015

Dilution Potential of PEARLITOL® Flash Formulated with Acetaminophen

See how PEARLITOL® Flash allows the production of robust orodispersible tablets even at high dilution.

28 May 2014

Study of the Influence of the Lubricant Ratio on the Tabletting Properties of PEARLITOL® Flash

PEARLITOL® Flash has been developed as a self-disintegrating mannitol compound for the formulation of ODTs by direct compression.

Study of the Disintegrating Properties of PEARLITOL® Flash

PEARLITOL® Flash is a compound of mannitol and starch, specially designed to disintegrate rapidly, providing a smooth texture without the addition of a superdisintegrant. In the present study, PEARLITOL® Flash's disintegration properties and mechanism were evaluated.

Optimising Excipient Properties for ODT Formulation

Compression forces and tablet hardness versus disintegration rate are key formulation factors. It's just a question of identifying the ODT excipient that would meet your requirements. The PEARLITOL® Flash white paper has the answer.

19 May 2014

NSAIDs Taste-Masking by New Maltodextrins (Kleptose Linecaps)

API's undesirable taste is one of the most challenging parameters when addressing patient compliance for oral drug delivery systems.

12 March 2014

Electronic Taste Sensing System to Evaluate Taste-Masking Properties of Maltodextrins

The aim of this study was to investigate the taste-masking capacity of different maltodextrin qualities compared with a known taste-masking substance by using an electronic taste sensing system.

Coating Heat-Sensitive Products at Ambient Temperature

See how LYCOAT® / ReadiLYCOAT® can be applied to your heat-sensitive ingredients or dosage forms at the same time as keeping the coating process short and providing an inert coating of perfect quality. And that’s not all...

21 February 2013

Roquette – Optimising Excipient Properties for ODT Formulation

Optimising Excipient Properties for ODT Formulation

21 November 2010

Press Release

3 November 2016

Roquette has announced that it will be attending the AAPS Annual Meeting and Exposition in Denver, showcasing its latest scientific solutions in plant-based pharmaceutical ingredients (API).

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13 September 2016

Roquette has announced it will attend the eighth EuPFI conference in Portugal.

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13 September 2016

For a wide range of oral dosage forms (solid and liquid), injectables, or dialysis, visit Roquette Pharma at CPhl to see its latest advances to help ensure patient safety.

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21 October 2013

See how LYCOAT® / ReadiLYCOAT® can be applied to your heat-sensitive ingredients or dosage forms at the same time as keeping the coating process short and providing an inert coating of perfect quality. And that's not all...

Read more
17 March 2013

Is Your Film Coating as Good as You Think it is?

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17 October 2011

Roquette Pharma's new natural inert polymer and ready to use coating system for fast aqueous film coating saves time by up to 50% or more.

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5 October 2011

Roquette is a long-established supplier of actives and excipients to the pharmaceutical and cosmetics industries. Our new slogan "Simply formulate your wishes" points to the many services we offer and to the strength of our underlying support. Whatever your requirements and aims, we are committed

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10 July 2011

Carbohydrates for injectable use are highly controlled pharmaceutical active ingredients that are essential in the preparation of large volume parenterals. These crucial life-saving medicines are taken for granted in all public health organisations and institutions. The large volume in

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Regional Offices

Roquette Pharma

Pharmaceutical & Cosmetics Business Unit

62080 LESTREM Cedex

Other

France

+33 3 21 63 36 00 +33 3 21 63 94 64 PEARLITOL® FLASH self-disintegrating filler www.roquette-pharma.com Taste-Masking Solutions DC Solutions

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