Biotage - Life Science Research Technologies

Biotage is a global company specialising in life science research technologies. The company offers products, knowledge and experience for genetic analysis, medicinal and analytical chemistry, and process development.

Customers include the world's top 30 pharmaceutical companies, the world's top 20 biotech companies, and leading academic institutes. Headquartered in Uppsala, Sweden, Biotage has subsidiaries in the US, Japan, Germany, the UK, and several other European countries.

LIFE SCIENCE RESEARCH TECHNOLOGY PRODUCTS

Biotage Discovery Chemistry Division products include microwave synthesis, resin-bound scavengers and reagents, Solid Phase Extraction (SPE), flash purification cartridges and systems, and evaporation and reaction screening instruments.

The company provides world-class on-site service and customer support, and is committed to continued development of future innovative products that speed the drug discovery process and deliver more accurate analysis.

INITIATOR™ MICROWAVE SYNTHESIS SYSTEMS

The Initiator microwave synthesiser enables medicinal chemists to quickly synthesise compounds using microwave heating. Chemists can easily load and run samples in just a few simple steps using the embedded touch-screen control and graphical user-interface.

The system has an expanded volume range of 0.2ml to 20ml with the EXP upgrade. For automated operation, an eight or 60-position robotic assembly can be added, expanding the system's functionality. All Biotage microwave synthesisers are designed to operate at elevated temperatures and pressures with best-in-class safety features.

POLYMER-BOUND REAGENTS

Polymer-bound reagents are functional polymers that perform synthetic transformations in the same way as their solution counterparts. Excess reagents and by-products remain attached to the resin, while the end product is purified by simple filtration.

SCAVENGER RESINS

Scavenger resins selectively react with excess reagents and reaction by-products to quench reactions and allow removal of bound chemicals by simple filtration. Using scavenger resins, chemists can save time and achieve compound purities exceeding 85% for many frequently-used reactions.

SILICA-BASED SORBENTS

Silica-based sorbents, functionalised with either a sulfonic acid group or a quaternary amine, can be used to isolate either basic or acidic compounds from reaction mixtures in catch and releases, and scavenging SPE.

ISOLUTE HM-N COLUMNS

ISOLUTE HM-N columns and 96-well plates, packed with a diatomaceous earth support, provide a simple and rapid approach to aqueous workup. This hydrophilic insert support can be used instead of traditional Liquid-Liquid Extraction (LLE) protocols, eliminating emulsion formation and improving reproducibility.

FLASH CHROMATOGRAPHY SYSTEMS AND CARTRIDGES

Prepacked flash purification cartridges and automated flash purification systems reduce compound separation time and increase throughput. SP™ systems operate at higher pressures using patented technology, increasing flow-through and reducing purification time.

A unique automated-method creation feature quickly creates sample-specific methods using TLC data. Built-in solvent monitoring, pressure control and fraction arm positioning ensure sample safety, eliminating any loss due to malfunction.

SP systems are available as single and multi-column systems, and reduce the time needed to achieve successful separations.

AQUEOUS AND ORGANIC SOLVENT EVAPORATION

Revolutionary new patented three-way drying technology speeds and improves solvent evaporation. The Biotage V-10 not only evaporates both aqueous and organic solvents up to 40 times faster than traditional rotary and centrifugal systems, but also protects the sample against bumping and overheating. Versatility and scalability eliminate handling and reformatting issues.

SPE SORBENTS AND FORMAT OPTIONS

IST sample preparation products provide analytical chemists with a comprehensive range of quality SPE sorbents and format options that deliver high reproducible analyte recoveries and extract purity. IST products provide practical solutions for analyte isolation for bioanalysis, forensic, environmental and agrochemical / food applications.

CHEMICAL DEVELOPMENT AND PRODUCTION-SCALE SYSTEMS

Biotage provides chemical development and production-scale systems to effectively bring new drugs to market. Built to last and engineered to perform, these systems help chemical engineers maximise their productivity by streamlining their processes and managing data.

Products include the Atlantis™ pressure scale-up system for hydrogenation reactions in parallel, Advantage Series™ 2410s, 3400s and 4100s for screening, optimization and validation of the chemical development workflow, and the FLASH 400 for production-scale purification.

SOLUTION-PHASE RESIN TOOLKIT

The new Biotage solution-phase resin toolkit offers medicinal chemists a convenient and economical way to explore reaction options for solution-phase chemistry. Simplify workup and purification by using polymer-bound reagents and scavengers that allow removal of excess substrates and byproducts from the reaction, by simple filtration.

The toolkit contains 14 resins with appropriate protocols for amidation, reductive amination, coupling and oxidation reactions. Streamline the workflow by integrating workup and purification with synthesis, saving time compared to conventional methods.