Malvern Instruments

Drug Development Technologies

Principles of Differential Scanning Calorimetry (DSC)

Malvern Instruments
Learn about the principles of Differential Scanning Calorimetry (DSC) Differential Scanning Calorimetry (DSC) is a technique for understanding the stability of proteins and other biomolecules. It has wide application in protein engineering, rational drug design and biopharmaceutical production, where developing stable proteins is a critical goal. MicroCal DSC microcalorimeters are powerful analytical tools for characterising the stability of proteins and other biomolecules, requiring minimal assay development, no labeling or immobilisation. The automation and high sensitivity afforded by MicroCal VP-Capillary DSC systems permits screening of large numbers of samples at low concentrations minimising the consumption of valuable samples with little hands-on effort.