Wave Biotech - Bioprocess Technology Equipment for Disposable Cell Cultivation

Wave Biotech AG develops, produces and distributes equipment for the biotechnology and pharmaceutical industries. We provide comprehensive support from equipment set-up to validation, as well as in-house equipment servicing. Wave Biotech has proved itself for a reliable partner on the way towards the disposable lab.

REESEALER® - LEAK FREE SEALS USING THERMOPLASTIC TUBING

The ReeSealer® is a fully automated device, designed to make permanent and consistent leak free seals using thermoplastic tubing. There is no laminar flow cabinet or similar environmental control device needed to guarantee sterility. The unit is sealing up to 19mm or 3/4in OD tubing such as C-Flex®, Pharmed®, Bioprene® or Sani-/Pharmapure.

The ReeSealer® is the complementation to the sterile tube fuser ReeWelder®3 that fuses together thermoplastic tubes up to 19mm or 3/4in OD in a sterile manner. Sealing process as well as welding process takes one minute only. This allows large and sterile fluid transfer from bag to bag or from bag to conventional reactors and media tanks, in a closed system.

WAVE FIBER OPTIC - SIMPLIFIED SENSORING

Disposable desolved oxygen (DO) and pH sensor for BioWave-reactors based on fiber optic measuring. This system includes an optical-chemical sensor, a polymer optical fibre and the BW-Controller. The optical-chemical sensor is mounted on a special sensor dip inside the Wave Bag®. The polymer optical fiber serves as a light-wave wire and is introduced into the sensor assembly without affecting the sterility of the single use Wave Bag®. The BW-Controller and amplifier measures the luminescence decay time of the immobilised luminophore.

BIOWAVE® - DISPOSABLE BIOREACTOR

This system enables you to achieve maximum cell counts and product yields while making significant savings in terms of time, costs and unnecessary validation. Batch, fed batch and continuous cultivation are performed in a pre-sterilised disposable Wave Bag.

The system includes a rocker unit and a Wave Bag®, a pre-sterilised disposable bioreactor chamber equipped with ports for sterile aeration, seeding, harvesting, sampling and analysis. The rocker unit is used to control and monitor temperature, aeration rate, and rocking speed. The optimal mixing and oxygen supply significantly increases and continuously renews the interface between the liquid and gaseous phases, resulting in bubble-free oxygen transfer. In addition, the wave motion guarantees optimum nutrient transfer and prevents the cells from settling, while maintaining minimum shear stress.

The BioWave® is designed for cultivation of human, animal, plant and insect cells, for bacterial and fungal cultures.

BioWave's key features: easy to use, scalable from 50ml to 100l, no cleaning, sterilisation, or complex tubing. The closed system rules out any risk of cross-contamination. The BioWave® principle also takes current ecological and economic requirements fully into consideration.

WAVE BAG® - DISPOSABLE BAG PRODUCTION AND CLEAN ROOM

Using our own manufacturing facilities, we design and produce standard and customised Wave Bags in all standard sizes and types as well as customised assemblies.

See also Drug Development Technology - Wave Biotech - A Swiss Alternative for Disposable Bioprocess Equipment