Bachem - Process Development and Manufacturing of Peptides and Complex Organic Molecules as APIs

Bachem is specialised in the process development and manufacturing of peptides and complex organic molecules as active pharmaceutical ingredients (APIs), as well as innovative biochemicals for research purposes. Bachem provides full service to the pharma and biotech industry. It is an independent, technology-based, public biochemicals company.

Bachem works on a global scale and holds a leading position in the field of peptides. Its headquarters are in Bubendorf, Switzerland, and it has affiliates in Europe and the US.

Research chemicals

Bachem's range of products is focused on peptide building blocks, natural and speciality amino acids, bioactive peptides, an impressive number of neuropeptides, peptide inhibitors, peptide substrates, and complex organic molecules, as well as resins and linkers for peptide synthesis. More than 9,000 products are available from stock.

Custom manufacturing of peptides and NCEs

Bachem has the experience and the required capacity for the custom synthesis of research peptides as well as for manufacturing new active ingredients (new chemical entities [NCEs]) for the biotech and pharmaceutical industry in conformity with the relevant GMP-regulations. Our customers can rely on full confidentiality.

Bachem offers custom peptide manufacturing in any scale and all related services from the early preclinical phases onwards. Bachem will support you during the earliest stages of your project, creating an optimal basis for a reliable partnership to be continued until market approval and beyond.

Generic APIs and active peptides

Bachem offers peptides and organic active ingredients whose patent protection has expired.

Considerable opportunities for growth in the field of generic APIs, active peptides as well as low-molecular ingredients, lie in innovative forms of delivery, such as sustained release formulations, and in new indications. Bachem's customers can apply for patent protection for such developments, giving them a potential similar to that of new chemical entities.

Bachem offers:

• Buserelin, Deslorelin, Fertirelin, Gonadorelin, Goserelin, Histrelin, Leuprolide, Nafarelin, Triptorelin Acetate, Triptorelin Pamoate
• Calcitonin (salmon), Elcatonin
• GRF (Somatorelin), GRF (1-29) amide (Sermorelin)
• Splenopentin, Thymopentin, Thymosin a (Thymalfasin), Thymosin ß4
• Aviptadil
• Exendin (9-39), GLP (7-36) amide, GLP-1 (7-37), Glucagon, Ghrelin, Neuropeptide Y, Peptide YY, Peptide YY (3-36)
• Somatostatin, Lanreotide, Octreotide
• pTH (1-34)
• CCK-4, Pentagastrin, Secretin, Sincalide
• Atosiban, Desmopressin, Terlipressin
• a-Melanotropin, Afamelanotide
• Angiotensin II, Bradykinin, CRF (Corticorelin), Dynorphin A (1-13), Endothelin-1, IGF-1 (1-3), Protirelin, Substance P, Tetracosactide (Cosyntropin)
• Acetylcysteine, Antazoline, Carbidopa, Carbocysteine, Cysteine, Dorzolamide, Econazole, Etomidate, L-NMMA (Tilarginine), Pergolide, Perindopril Erbumine, Propofol, Resveratrol, Timonacic, Trandolapril, Trimetazidine, Xipamide, Xylazine, Zonisamide

Peptides in finished dosage form (FDF)

Bachem not only offers the peptide API, but also the finished dosage form (FDF). Clinical trial material in vials, ampoules and pre-filled syringes - released by Bachem's Qualified Person (QP) - is available through Bachem's fully owned subsidiary in Germany (Clinalfa® brand).

This service fulfils our customers' needs and shortens time to market: from research-grade chemicals and custom synthesis of peptides or complex organic molecules, to GMP-compliant manufacturing of NCEs and eventually to peptides in finished dosage form.

Manufacturing of cytostatic and cytotoxic peptides

Bachem also offers custom manufacturing of cytostatic and cytotoxic peptides and complex organic molecules. These substances are used as active ingredients for cancer medication. They have to be manufactured in dedicated facilities following the strictest safety regulations to protect both staff and the environment.

Full regulatory support

Bachem has the experience and the financial resources to meet growing regulatory and GMP demands. We have already submitted dozens of technical packages in support of successful IMPD and IND applications.