Macrocap SP Purification Medium Offers High Yield Of Large, Pegylated Biomolecules
10 February 2006
GE Healthcare has announced the availability of MacroCap™ SP, a large-pore cation exchange medium for downstream processing that gives high purity and yield of large size biomolecules, such as polyethylene glycol (PEG) - modified proteins.
Designed for the purification of large biopharmaceuticals (MW > 150,000), MacroCap SP is a large pore ion-exchange medium that allows separation of mono- from oligo- and non-PEGylated proteins, with high selectivity and yield under high load conditions. Further enhancing its cost-effectiveness, MacroCap offers good Cleaning-In-Place (CIP) stability for ease of use and long media lifetime.
"MacroCap SP has mass transfer properties suitable for large biomolecules, making it ideal for use in purifying PEGylated drug compounds such as recombinant proteins", says Torgny Lindback, marketing director of industrial separations, protein separations at GE Healthcare. "The process of PEGylation greatly increases the size of the native protein, lowers its average surface charge and produces undesirable by-products. Thus, a high yield medium such as MacroCap SP is critical for maximizing recovery of high purity product as efficiently as possible. In addition, its good chemical stability allows CIP to be performed in both acidic and alkaline conditions."
MacroCap SP joins GE Healthcare's line of BioProcess™ media, which are designed to meet the demands of industrial biotechnology and are scalable from laboratory to production.
