Malvern Instruments

Drug Development Technologies

Stability Characterisation Using Differential Scanning Calorimetry

Malvern Instruments

An important parameter in production, manufacturing, formulation, and long-term storage, protein stability has large effects on biopharmaceutical products and higher stability means for greater profits and less product waste.

In the quality-by-design (QBD) approach, stability characterisation is part of the developability of a potential drug candidate and biophysical tools are used to determine their suitability.

Differential scanning calorimetry (DSC) plays a crucial role in characterisation of thermal stability. Download this free whitepaper to find out more, including topics such as an outline of DSC, higher order structure (HOS) comparability of biopharmaceuticals through case studies using DSC, and using DSC for characterisation of biosimilars.

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