Specifications - ChemSyn (Aptuit) Pharmaceutical Manufacturing Plant, Harrisonville, Montana, USA
| Key Data | |
|---|---|
| Start year | 1998 |
| Project type | Manufacturing plant for APIs, but also process development |
| Location | Harrisonville, USA |
| Estimated investment | $5m (new investment expected in 2007–2008 following takeover) |
| Completion | 1999 |
| Key Players | |
| Sponsor | ChemSyn Laboratories (EaglePitcher Technologies) |
| Lead contractor | Pfaudler supply the reactors. Buchii supply the chemreactor. Hamicon and Hastelloy supply some of the filter equipment |
| Technical Specification | |
| Plant suites | 1 development work suite and 2 production suites |
| Glove box | 50l |
| Reactors and process vessels | 10gal glass-lined Pfaudler reactor |
| 30gal glass-lined Pfaudler reactor (2) | |
| 30gal stainless steel Pfaudler reactor | |
| 50gal glass-lined Pfaudler reactor (2) | |
| 100gal glass-lined Pfaudler reactor (3) | |
| 200gal glass-lined Pfaudler reactor | |
| 300gal glass-lined Pfaudler reactor (2) | |
| 300gal stainless steel Pfaudler reactor | |
| 50gal stainless steel kettle (2) | |
| 75gal glass-lined kettle | |
| 80gal miscellaneous receivers | |
| 50gal glass-lined receiver (2) | |
| 200gal glass-lined receiver | |
| 1,580gal storage tank | |
| Glassware | Microware through 72l flasks |
| 100l Buchii ChemReactor | |
| Cooling and heating | Dow Frost chiller (720,000 BTU/hr at-30_C) |
| Supersaturated steam (150°C at 75 psi) | |
| Hot oil system for higher temperatures | |
| Blenders | Stainless steel ribbon blender (3 cubic feet working capacity) |
| Twin shell V-blender (1 cubic foot) | |
| Twin shell V-blender (16 qt.) | |
| Dryers | Stainless steel rotary cone dryer (5 cubic feet working capacity) |
| Stainless steel vacuum ovens (7.5 cubic feet) (3) | |
| Stainless steel Stokes Vacuum Tray Dryer | |
| Freeze-dryer (12l) | |
| Distillation equipment | Rotary evaporators (10 & 20l) (2) |
| Stainless steel wiped film evaporator (0.25ft²) | |
| Fractionation column (15 HETP-3` x 1") | |
| Filtration equipment | Basket centrifuges-stainless steel (24") |
| Sparkler filter-Hastelloy | |
| Sparkler filter-stainless steel | |
| Amicon DC-10L Dialysis-filtration system | |
| Pumps | 150cfm NASH pump |
| 30cfm NASH pump | |
| 40cfm high vacuum oil pump | |
| 300cfm high vacuum oil pump | |
| Miscellaneous: drum, transfer and metering pumps | |
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