View all newsletters
Receive our newsletter - data, insights and analysis delivered to you
  1. Comment
August 2, 2021

Pfizer and Moderna Covid-19 vaccines usage and updated safety labels

New reports indicate an increased risk of myocarditis or pericarditis after being given either of Pfizer or Moderna's Covid-19 vaccines.

By GlobalData Healthcare

Since early last March, numerous companies have been working to develop effective vaccines against SARS-CoV-2, the virus responsible for Covid-19. Among those, Pfizer’s Comirnaty and Moderna’s Spikevax vaccines have found the greatest success, with an efficacy rate of almost 95%. The Covid-19 Dashboard on GlobalData’s Pharma Intelligence Centre tracks emerging information effectively, and in countries such as the US, Comirnaty and Spikevax were shown to lead against other Covid-19 vaccines in both contract volume and administration (see Figures 1 and 2). As of 4 July, 276 and 35 million doses of Comirnaty and Spikevax had also been administered respectively within the European Union (EU).

Free Whitepaper
img

What is the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry?

While wanting to protect the country from being overwhelmed by Omicron, China’s adherence to a Zero-COVID policy is resulting in a significant economic downturn. COVID outbreaks in Shanghai, Beijing and many other Chinese cities will impact 2022’s economic growth as consumers and businesses experience rolling lockdowns, leading to a slowdown in domestic and international supply chains. China’s Zero-COVID policy is having a demonstrable impact on consumer-facing industries. Access GlobalData’s new whitepaper, China in 2022: the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry, to examine the current situation in Shanghai and other cities in China, to better understand the worst-affected industry sectors, foodservice in particular, and to explore potential growth opportunities as China recovers. The white paper covers:
  • Which multinational companies have been affected?
  • What is the effect of lockdowns on foodservice?
  • What is the effect of lockdowns on Chinese ports?
  • Spotlight on Shanghai: what is the situation there?
  • How have Chinese consumers reacted?
  • How might the Chinese government react?
  • What are the potential growth opportunities?
by GlobalData
Enter your details here to receive your free Whitepaper.

Despite this, new conflicting information has come out via emerging reports on EudraVigilance, the EU database used for monitoring and analysing suspected side effects. These reports indicate an increased risk in inflammation of the heart muscle (myocarditis) or membrane (pericarditis) following vaccination with either Comirnaty or Spikevax. Other known or potential side effects include asthaenia, lethargy and nocturnal hyperhidrosis for Comirnaty and anaphylaxis, delayed injection site reaction and immune thrombocytopenia for Spikevax. Both of these messenger ribonucleic acid (mRNA) vaccines also carry the risk of inducing immediate allergic reactions, usually within four hours of exposure; symptoms of these include hives, swelling or wheezing.

A safety assessment carried out by the Pharmacovigilance Risk Assessment Committee (PRAC) has confirmed an increased risk of myocarditis and pericarditis, stating that most cases occurred 14 days after vaccination, more often after the second dose and in younger adult men. As a result, both vaccines’ product information will now include details of new side effects, raising awareness of the increased risk of these disorders.

Studies have shown that vaccine acceptance has predominantly been hindered by concerns around side effects and vaccine efficacy, resulting in acceptance being below estimates required for herd immunity in many countries. As the link between Covid-19 case numbers and hospitalisations has weakened due to vaccines being administered, however, there has been recent growth in their acceptance. There may, therefore, be concerns that this new announcement will impede the usage of the Pfizer and Moderna Covid-19 vaccines, particularly at a time when many people have received the first dose but have yet to receive the second.

Despite this, the European Medical Agency (EMA) believes that the benefits of both vaccines far outweigh their risks and, as a result, there is a strong possibility that this will not impact vaccine uptake. Important is the fact that other vaccines have previously reported rare side effects, such as the AstraZeneca brand, which has been linked to a rare blood clotting disease. AstraZeneca’s vaccine has, nonetheless, remained the second most administered Covid-19 vaccine in many European countries, which suggests that this may not be a significant factor in the continued uptake of either Comirnaty or Spikevax.

Related Companies

Free Whitepaper
img

What is the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry?

While wanting to protect the country from being overwhelmed by Omicron, China’s adherence to a Zero-COVID policy is resulting in a significant economic downturn. COVID outbreaks in Shanghai, Beijing and many other Chinese cities will impact 2022’s economic growth as consumers and businesses experience rolling lockdowns, leading to a slowdown in domestic and international supply chains. China’s Zero-COVID policy is having a demonstrable impact on consumer-facing industries. Access GlobalData’s new whitepaper, China in 2022: the impact of China’s Zero-COVID lockdowns on economic activity, consumer goods and the foodservice industry, to examine the current situation in Shanghai and other cities in China, to better understand the worst-affected industry sectors, foodservice in particular, and to explore potential growth opportunities as China recovers. The white paper covers:
  • Which multinational companies have been affected?
  • What is the effect of lockdowns on foodservice?
  • What is the effect of lockdowns on Chinese ports?
  • Spotlight on Shanghai: what is the situation there?
  • How have Chinese consumers reacted?
  • How might the Chinese government react?
  • What are the potential growth opportunities?
by GlobalData
Enter your details here to receive your free Whitepaper.

NEWSLETTER Sign up Tick the boxes of the newsletters you would like to receive. A weekly roundup of the latest news and analysis, sent every Friday. The pharmaceutical industry's most comprehensive news and information delivered every month.
I consent to GlobalData UK Limited collecting my details provided via this form in accordance with the Privacy Policy
SUBSCRIBED

THANK YOU

Thank you for subscribing to Pharmaceutical Technology