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July 22, 2020

The NIH’s innovative approach to streamlining Covid-19 vaccine and drug development: The ACTIV initiative

By GlobalData Healthcare

The US National Institute of Health (NIH) launched the Accelerating Covid-19 Therapeutic Interventions and Vaccines (ACTIV) initiative, a public-private partnership effort to address the Covid-19 public health emergency, said Dr Matthew McMahon, Director of the NIH Office of Biomedical Entrepreneurship and Innovation, speaking about NIH’s response to the global health crisis during the panel session titled “The Key Role of NIH in the Product Development Pipeline” at the Biotechnology Innovation Organization (BIO) Digital International Convention on June 9. This innovative program focuses on speeding up the development of vaccines and treatments for Covid-19 by developing a coordinated research strategy and aims to make use of limited biomedical research resources in the most efficient way. NIH has made efforts to become more flexible by providing “extensive grant application flexibility… [and] access to supplements and competitive revisions to existing grants [as a way to support researchers during these unprecedented times],” added McMahon. NIH is the largest biomedical research funder in the world, focused on all diseases and platforms, supporting over 2,800 research institutions and 300,000 researchers globally.

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COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
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With numerous vaccines and therapeutics in the pipeline, NIH’s ACTIV program aims to identify the most promising, over those with less potential, to accelerate their development and prevent the wasteful duplication of clinical trials. According to the Drugs Database and Coronavirus Disease 2019 (Covid-19) Dashboard on GlobalData’s Pharma Intelligence Center, there are currently over 250 vaccines and 700 therapeutics in Discovery to Phase III stages of development for Covid-19. The program has four focus areas, designed to: identify preclinical treatments, accelerate clinical testing of the most promising vaccines and treatments, improve clinical trial capacity and effectiveness, and accelerate the evaluation of vaccine candidates to enable rapid authorisation or approval.

Through this initiative, the NIH is partnering with a range of other agencies such as Biomedical Advanced Research and Development Authority (BARDA), Centers for Disease Control and Prevention (CDC), the FDA, the European Medicines Agency (EMA), and representatives from academia, non-profit organisations, and 18 private biopharmaceutical companies, including big industry players AstraZeneca, Pfizer, GlaxoSmithKline, and Novartis, among others.

McMahon said another aspect through which the NIH is supporting the global fight against Covid-19 is the Rapid Acceleration of Diagnostics (RADx) initiative, which aims to fast-track Covid-19 test development and commercialisation. He added, “The goal is to develop new diagnostic tests that can accelerate our ability to get back to work and get back to school and effectively open up the country [the US] by the fall.” A holistic approach, which includes widespread Covid-19 testing to identify who has been infected and hence are at risk of spreading the virus, will indeed prove pivotal in containing the disease.

In spite of the swift and extraordinary response from numerous biopharmaceutical companies and researchers around the world, a coordinated and collaborative approach to streamline research efforts will be key in ensuring those promising vaccines, treatments, and diagnostic tests reach the global community fast to help bring the pandemic under control.

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Navigate your business through the ‘new normal’

COVID-19 continues to dominate headlines the world over. It has already affected our lives forever. The way we work, shop, eat, seek medical advice, and socialize will all be different in the future. Quite how different remains to be seen, but all industries must plan for multiple eventualities.  Faced with an explosion of conflicting information on how to plan and implement successful recovery strategies, decision-makers are in dire need of a single, reliable source of intelligence.   GlobalData’s COVID-19 Executive Briefing gives you access to unparalleled data and insights to successfully navigate the uncertain road to recovery across the world’s largest industries. Understand every aspect of this disruptive theme by delving into: 
  •  COVID-19 infection update, with statistics on the spread, testing by country, as well as the latest data on vaccines and therapeutic developments 
  • Economic impact overview, covering stock market indices, GDP, unemployment rates, policy responses & GlobalData’s economic recovery scorecards 
  • Sector developments, with access to sector insight summaries, cross-sector indices and the leaders and laggards in each industry vertical 
Whatever your company’s imminent strategic plans, the long-lasting impact of COVID-19 must not be overlooked. Find out how to futureproof your business operations – download our report today. 
by GlobalData
Enter your details here to receive your free Report.

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