PARP inhibitors have recently been pushed to the forefront of many avenues of cancer research. Poly ADP-ribosylation is a post-translational modification of proteins that plays a crucial role in regulating DNA repair. Polymerases (PARP) catalyse the reaction with the help of NAD+. PARP inhibitors have been shown to potentiate the cytotoxcity of anti-cancer drugs and are therefore extremely interesting target compounds for cancer research.
BMG LABTECH’s FLUOstar Omega has been proven to be an important tool in the screening of PARP inhibitors. This multi-detection microplate reader is able to perform the complex assays needed for the evaluation of PARP inhibitors. The capability of the FLUOstar Omega to read numerous detection modes including fluorescence, luminescence and absorbance, facilitates simple and rapid measurement of all aspects of PARP inhibitor evaluation using a single machine. For more information, please contact BMG LABTCH or visit our website (see company profile).