Acazicolcept is under clinical development by Alpine Immune Sciences and currently in Phase I for Rheumatoid Arthritis. According to GlobalData, Phase I drugs for Rheumatoid Arthritis have a 71% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Acazicolcept’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Acazicolcept overview

Acazicolcept is under development for the treatment of rheumatoid arthritis, psoriatic arthritis, multiple sclerosis, inflammatory bowel disease, hemophagocytic lymphohistiocytosis, sicca syndrome (sjogren), uveitis, type I diabetes, systemic lupus erythematosus and graft versus host disease (GVHD). It acts by targeting inducible T-cell costimulator (ICOS) and T cell-specific surface glycoprotein CD28 (CD28). It is administered by intravenous or subcutaneous routes as an injection. The drug candidate is developed based on the variant immunoglobulin domain (vIgD) platform technology. It is a fusion protein, synthesized by combining vIgDs with antibody Fc domains.

Alpine Immune Sciences overview

Alpine Immune Sciences (Alpine), formerly Nivalis Therapeutics Inc, is a pharmaceutical company that focuses on discovering and developing innovative, protein-based immunotherapies to treat cancer and autoimmune and inflammatory diseases. It provides ALPN-101 and ALPN-303 for the treatment of based immunotherapies and immune synapses to treat cancer and autoimmune and inflammatory diseases. Nivalis Therapeutics’ ALPN-101’s potential for the treatment of inflammatory diseases. The company offers a proprietary scientific platform that converts native immune system proteins into differentiated, multi-targeted therapeutics. Nivalis Therapeutics is headquartered in Seattle, Washington, the US.

For a complete picture of Acazicolcept’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.