ACT-101 is under clinical development by Alpha Cancer Technologies and currently in Phase I for Hashimoto Thyroiditis. According to GlobalData, Phase I drugs for Hashimoto Thyroiditis does not have sufficient historical data to build an indication benchmark PTSR for Phase I. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the ACT-101 LoA Report. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

ACT-101 overview

ACT-101 is under development for the treatment of myasthenia gravis, multiple sclerosis, colorectal cancer, Crohn's disease, Hashimoto thyroiditis, ulcerative colitis and other IgG-driven diseases. The drug candidate is administered by subcutaneous route. ACT-101 is a genetically engineered recombinant version of a naturally occurring protein known as alpha fetoprotein (AFP) which acts by targeting neonatal Fc receptor (FcRn) and is an immunomodulatory agent. It was also under development for uveitis, rheumatoid arthritis, chronic plaque psoriasis and systemic lupus erythematosus.

Alpha Cancer Technologies overview

Alpha Cancer Technologies (ACT) is a clinical stage biotechnology company that offers development in oncology and auto-immune disease indications. The company products include alpha fetoprotein, immunology platform and targeted chemotherapy platform. It manufACTures products using its proprietary recombinant human alpha fetoprotein with immuno-oncology properties. ACT includes drug master file with FDA manufACTuring, toxicology and human safety. The company provides treatment for myasthenia gravis, multiple sclerosis and autoimmune encephalitis and lupus. It also includes chemotherapy platform for the treatment of solid and liquid tumors. The company collaborates with healthcare universities, cancer and polytherics institutions. ACT is headquartered in Toronto, Ontario, Canada.

For a complete picture of ACT-101’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 2 September 2023

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.