Adagrasib is under clinical development by Mirati Therapeutics and currently in Phase II for Solid Tumor. According to GlobalData, Phase II drugs for Solid Tumor have a 10% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Adagrasib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Adagrasib overview

Adagrasib (Krazati) belongs to the RAS GTPase family, an antineoplastic agent. It is formulated as film coated tablets for oral route of administration. Krazati is indicated for the treatment of adult patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC).

Adagrasib is under development for the treatment of solid tumors including advanced colorectal cancer, squamous or non-squamous non-small cell lung cancer, colorectal cancer, ovarian cancer, endometrial cancer, bile duct cancer, metastatic pancreatic cancer and pancreatic ductal adenocarcinoma. It is administered by the oral route as a tablet. The drug candidate acts by targeting KRAS G12C mutations.

Mirati Therapeutics overview

Mirati Therapeutics is a clinical-stage oncology company that developing novel therapeutics to address the genetic and immunological promoters of cancer. The company product pipeline includes Adagrasib (MRTX849), an oral small molecule inhibitor of KRASG12C and MRTX1133, a potent small molecule inhibitor of the KRASG12D for the treatment of colorectal and pancreatic cancer. Mirati Therapeutics is also evaluating Sitravatinib, a multi kinase inhibitor against non-small cells lung cancer in non-smokers and MRTX1719 to treat MTAP deleted cancers. The company has partner with Zai Lab, Beigene, Sanofi, Boehringer, Novartis and Bristol Myers Squibb, among others. It operates in Canada, Netherlands and the US. Mirati Therapeutics is headquartered in San Diego, California, the US.

For a complete picture of Adagrasib’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.