Aflibercept is under clinical development by Regeneron Pharmaceuticals and currently in the Phase I, Phase II, Phase III and Pre-Registration in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.
According to GlobalData, the latest event to affect Aflibercept’s likelihood of approval (LoA) and phase transition for Age Related Macular Degeneration took place on 04 Aug 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.
GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Aflibercept Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.
Aflibercept (Eylea) is a recombinant fusion protein consisting of portions of human VEGF receptors 1 and 2 extracellular domains fused to the Fc portion of human IgG1. Eylea is formulated as an iso-osmotic injection solution for intravitreal route of administration. Eylea is indicated for treatment of neovascular (wet) age-related macular degeneration (wet AMD) and for the treatment of macular edema following central retinal vein occlusion. It is also indicated for non-proliferative diabetic retinopathy (NPDR), diabetic macular edema(DME) and Diabetic Retinopathy (DR) in Patients with DME, for the treatment of choroidal neovascularization and macular edema secondary to branch retinal vein occlusion (BRVO), for the treatment of visual impairment due to myopic choroidal neovascularization (myopic CNV), and all stages of non-proliferative diabetic retinopathy (DR), and thereby reduce the risk of blindness. It is based on trap technology.
Aflibercept is under development for the treatment of retinopathy of prematurity (ROP), diabetic retinopathy, radiation retinopathy including maculopathy, optic neuropathy, non-proliferative diabetic retinopathy (NPDR), acute thyroid eye disease and diabetic macular edema at high dose. The drug candidate was also under development for the treatment of corneal neovascularization. It is administered through intravitreal or parenteral or subconjunctival as a solution form.
Regeneron Pharmaceuticals overview
Regeneron Pharmaceuticals (Regeneron) is engaged in discovering, developing, manufacturing, and marketing medicines for the treatment of serious medical conditions. Its products are focused on helping patients suffering from cancer, allergic and inflammatory diseases, eye diseases, metabolic and cardiovascular diseases, infectious diseases, neuromuscular diseases, and rare diseases. It develops products using its Trap and VelociSuite technology platforms, which include VelocImmune, VelociGene, VelociMouse, VelociMab, Veloci-Bi, and other related technologies. The company operates manufacturing facilities in Rensselaer, New York, and Limerick, Ireland. It also collaborates with strategic partners to develop, manufacture, and commercialize its products. It sells its products to specialty pharmacies and distributors. The company operates in the US, the Netherlands, Bermuda, Ireland, Spain, and the UK. Regeneron is headquartered in Tarrytown, New York, the US.
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