Afuresertib hydrochloride is under clinical development by Laekna Therapeutics Shanghai and currently in the Phase II and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Afuresertib hydrochloride’s likelihood of approval (LoA) and phase transition for Metastatic Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer took place on 12 Sep 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Afuresertib hydrochloride Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Afuresertib hydrochloride overview

Afuresertib hydrochloride (GSK2110183, ASB-183) is under development for the treatment of solid tumors, metastatic castration resistant prostate cancer, HR+/HER2- breast cancer, triple-negative breast cancer, ovarian clear cell carcinoma, fallopian tube cancer, primary peritoneal cancer, ovarian carcinosarcoma and ovarian sarcoma. The drug candidate is administered orally. It is an inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It was also under development for ovarian cancer, fallopian tube cancer, peritoneal cancer, gastric cancer, gastroesophageal junction carcinoma and relapsed multiple myeloma, metastatic castration-resistant prostate cancer (mCRPC), breast cancer, renal cell carcinoma, non-small cell lung cancer, colorectal cancer, melanoma, head and neck cancer, pancreatic cancer, bladder cancer, hepatocellular cancer, endometrial cancer, refractory multiple myeloma and Langerhans cell histiocytosis and solid tumors and hematological tumors including relapsed or refractory chronic lymphocytic leukemia (CLL), cervical cancers like cervical squamous cell carcinoma, adenosquamous carcinoma, adenocarcinoma, endometrial cancers like endometrioid adenocarcinoma, high-grade serous carcinoma, or clear cell carcinoma, metastatic esophageal squamous cell carcinoma or Her2-negative adenocarcinoma, NSCLC (squamous cell carcinoma or adenocarcinoma, adenosquamous carcinoma), gastric adenocarcinoma and esophagogastric junction adenocarcinoma.

Laekna Therapeutics Shanghai overview

Laekna Therapeutics Shanghai, a biotech company that focused on innovative drug discovery and development. The company is headquartered in China.

Quick View Afuresertib hydrochloride LOA Data

Report Segments
  • Innovator
Drug Name
  • Afuresertib hydrochloride
Administration Pathway
  • Oral
Therapeutic Areas
  • Genetic Disorders
  • Oncology
Key Developers
Highest Development Stage
  • Phase III

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.