Aloradine is a small molecule commercialized by VistaGen Therapeutics, with a leading Phase III program in Social Anxiety Disorder (SAD/Social Phobia). According to Globaldata, it is involved in 12 clinical trials, of which 8 were completed, 1 is ongoing, 2 are planned, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Aloradine’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for Aloradine is expected to reach an annual total of $73 mn by 2032 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

Aloradine Overview

fasedienol (PH-94B) is under development for the treatment of social anxiety disorders (social phobia), postpartum anxiety, post-traumatic stress disorder, pre-proceduralanxiety (pre-MRI) and adjustment disorder with anxiety related to the COVID-19 pandemic. It is a intranasally administered as neurosteroidal aerosol. PH-94B belongs to a family of pharmaceutical compounds called pherines. It was also under development for the treatment of generalized anxiety disorder.

VistaGen Therapeutics Overview

VistaGen Therapeutics (VistaGen) is a clinical stage biopharmaceutical company that develops new generation medicines for depression and neuropsychiatric disorders. The company’s pipeline product, AV-101, currently under Phase 2 clinical development, is an oral N-methyl-D-aspartate receptor glycine B intended to treat the major depressive disorder. Its other pipeline products comprise of PH94B treats social anxiety disorder and PH10 nasal spray treats for major depressive disorder. The company offers its products in the form of sprays and oral. It partners with other healthcare industries for researching and assessing drug effects on cardiac risk. VistaGen is headquartered in South San Francisco, California, the US.

The company reported revenues of (US Dollars) US$1.1 million for the fiscal year ended March 2022 (FY2022), an increase of 1.8% over FY2021. The operating loss of the company was US$47.8 million in FY2022, compared to an operating loss of US$17.9 million in FY2021. The net loss of the company was US$47.8 million in FY2022, compared to a net loss of US$17.9 million in FY2021.

For a complete picture of Aloradine’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.