Alteplase is under clinical development by F. Hoffmann-La Roche and currently in Phase II for Bronchitis. According to GlobalData, Phase II drugs for Bronchitis have a 77% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Alteplase’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Alteplase overview

Alteplase (Actilyse, Activacin, Grtpa, Cathflo, Cathflo Activase, Lysatec, Actilyse Cathflo) is a thrombolytic agent. It is formulated as powder for solution for intravenous route of administration. It is indicated in thrombolytic treatment in acute myocardial infarction, acute massive pulmonary embolism with haemodynamic instability, fibrinolytic treatment of acute ischemic stroke, improvement of dysfunction associated with ischemic cerebrovascular disorder acute phase and coronary artery thrombosis in acute myocardial infarction. It is also indicated for the restoration of function to central venous access devices as assessed by the ability to withdraw blood.

Alteplase is under development for the treatment of plastic bronchitis (inhalational).

It was also under development for the treatment of acute respiratory distress syndrome (ARDS) triggered by COVID-19 and intracerebral hemorrhage (ICH).

F. Hoffmann-La Roche overview

F. Hoffmann-La Roche (Roche) is a biotechnology company that develops drugs and diagnostics to treat major diseases. It provides medicines for the treatment of cancer, other auto-immune diseases, central nervous system disorders, ophthalmological disorders, infectious diseases, and respiratory diseases. The company also offers in vitro diagnostics, tissue-based cancer diagnostics, and diabetes management solutions. Roche conducts research to identify novel methods to prevent, diagnose, and treat diseases. The company offers its products and services to hospitals, healthcare professionals, commercial laboratories, researchers, and pharmacists. Together with its subsidiaries and partners, the company has operations in various countries. Roche is headquartered in Basel, Switzerland.

For a complete picture of Alteplase’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.