Apatinib mesylate is under clinical development by Advenchen Laboratories and currently in the Phase I, Phase II and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Apatinib mesylate’s likelihood of approval (LoA) and phase transition for Triple-Negative Breast Cancer (TNBC) took place on 17 Oct 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

In addition, the same event on 17 Oct 2022 increased Apatinib mesylate’s LoA and decreased Phase Transition Success Rate (PTSR) for Breast Cancer, and increased LoA and decreased PTSR for Non-Small Cell Lung Cancer.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Apatinib mesylate Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Apatinib mesylate overview

Apatinib Mesylate (Aitan) is an anti-neoplastic agent. It is formulated as film-coated tablets for oral route of administration. Apatinib is indicated in treatment for metastatic gastric cancer and hepatocellular carcinoma.

Apatinib (YN968D1) is under development for the treatment of advanced right-sided colon cancer, retroperitoneal sarcomas, osteosarcoma, liver metastasis of gastrointestinal pancreatic neuroendocrine tumor (GEP-NET), neuroendocrine tumors,  metastatic pancreatic cancer, soft tissue sarcoma, metastatic hepatocellular carcinoma, metastatic gastric cancer, adenocarcinoma of gastroesophageal junction, metastatic adenoid cystic carcinoma, relapsed/refractory non-squamous non-small cell lung cancer (NSCLC), metastatic colorectal cancer, gestational trophoblastic neoplasia(GTN),  intrahepatic cholangiocarcinoma, small-cell lung cancer, metastatic triple-negative breast cancer, progressive/metastatic refractory thyroid cancer, epithelial ovarian cancer, esophageal squamous cell carcinoma, metastatic head and neck squamous cell carcinoma, metastatic esophageal squamous cell carcinoma, recurrent cervical cancer, endometrial cancer, relapsed or refractory extranodal nasal type NK/T cell lymphoma, peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma and anaplastic large cell lymphoma, non-metastatic nasopharyngeal carcinoma (NPC) that have residual Epstein-Barr virus (EBV), gallbladder cancer, thymic epithelial tumor, recurrent high-grade glioma, papillary thyroid cancer, medullary thyroid cancer, follicular thyroid cancer, recurrent glioblastoma multiforme, advanced lung adenocarcinoma, advanced malignant melanoma, metastatic advanced biliary tract carcinoma, urothelial carcinoma, peritoneal cancer, fallopian tube cancer renal cell carcinoma and primary pulmonary lymphoepithelioid carcinoma, synovial sarcoma, leiomyosarcoma, angiosarcoma, undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma, liposarcoma, fibrosarcoma, clear cell sarcoma, epithelioid sarcoma, malignant peripheral nerve sheath tumor, undifferentiated sarcoma, rhabdomyosarcoma, dermatofibrosarcoma protuberans, Ewing’s sarcoma /primary neural ectoderm tumors, desmoplastic small round cell tumor, inflammatory myofibroblastic sarcoma, malignant solitary fibroma, gastroesophageal (GE) junction carcinomas and radiation-induced brain injury. It was also under development for the treatment of gastrointestinal stromal tumor (GIST), NSCLC, triple negative breast cancer and colorectal cancer.

Advenchen Laboratories overview

Advenchen Laboratories is a pharmaceutical company that offers healthcare solutions. The company conducts pharmaceutical research and develops small molecule cancer drug discovery programs. It provides pipeline such as angiogenesis inhibitors and small molecule protein tyrosine kinases inhibitors, among others. Advenchen Laboratories provides services such as producing inhibitors for the treatment of human colon cancer, liver cancer, gastric cancer, lungs and breast cancer, among others. Advenchen Laboratories also provides customized chemical intermediate services. The company operates in China and the US. Advenchen Laboratories is headquartered in Moorpark, California, the US.

Quick View Apatinib mesylate LOA Data

Report Segments
  • Innovator (Non-NME)
Drug Name
  • Apatinib mesylate
Administration Pathway
  • Oral
Therapeutic Areas
  • Infectious Disease
  • Oncology
  • Toxicology
Key Developers
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.