APG-5918 is under clinical development by Ascentage Pharma Group and currently in Phase I for Malignant Mesothelioma. According to GlobalData, Phase I drugs for Malignant Mesothelioma have a 74% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how APG-5918’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

APG-5918 overview

APG-5918 is under development for the treatment of beta-thalassemia, metastatic solid tumors or relapsed or refractory non-Hodgkin's Lymphoma, nasopharyngeal carcinoma, castration-resistant prostate cancer, B-cell non-Hodgkin lymphoma, IN1-negative malignant rhabdoid tumor, gastric cancer, ovarian clear cell carcinoma, mesothelioma, b cell lymphoma, sickle cell disease, diffuse large B cell lymphoma (DLBCL), SMARCB1-deficient malignant rhabdoid tumor,solid tumor, hematological tumor, anemia and unspecified indication. It is administered through oral route. It acts by targeting polycomb protein EED.

Ascentage Pharma Group overview

Ascentage Pharma Group (Ascentage Pharma), a subsidiary of Ascentage Pharma Group International, is a biotechnology company that develops therapies for cancers and senesce diseases. Ascentage Pharma is headquartered in Rockville, Maryland, the US.

For a complete picture of APG-5918’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 2 September 2023

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.