ARV-766 is a small molecule commercialized by Arvinas, with a leading Phase II program in Metastatic Castration-Resistant Prostate Cancer (mCRPC). According to Globaldata, it is involved in 2 clinical trials, which are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of ARV-766s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for ARV-766 is expected to reach an annual total of $48 mn by 2037 in the US based off GlobalDatas Expiry Model. The drugs revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drugs phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
ARV-766 Overview
ARV-766 is under development for the treatment of metastatic castration resistant prostate cancer. It is administered through oral route. The drug candidate is a heterobifunctional PROTAC (proteolysis-targeting chimera) and acts by targeting androgen receptor and an E3 ubiquitin ligase.
Arvinas Overview
Arvinas is a biopharmaceutical company that develops protein degradation therapeutics. The company develops novel therapeutics for the treatment of neuroscience, oncology, and other therapeutic areas. Its pipeline product includes oncology and immuno-oncology pipeline and Neuroscience pipeline. Oncology and immuno-oncology pipeline products include Vepdegestrant (ARV-471), Bavdegalutamide (ARV-110), ARV-766, ARV-393, AR-V7, HPK1 (I-O Program), KRAS-G12D/V, Myelocytomatosis (Myc) proteins. Neuroscience pipeline products include ARV-102, Alpha, Synuclein, mHTT, Tau. The company intends to expand its transformative protein degradation technology and its product candidates into clinical development through collaborations with pharmaceutical companies. Arnivas is headquartered in New Haven, Connecticut, the US.
The company reported revenues of (US Dollars) US$78.5 million for the fiscal year ended December 2023 (FY2023), a decrease of 40.3% over FY2022. The operating loss of the company was US$401.5 million in FY2023, compared to an operating loss of US$263.2 million in FY2022. The net loss of the company was US$367.3 million in FY2023, compared to a net loss of US$282.5 million in FY2022.
The company reported revenues of US$25.3 million for the first quarter ended March 2024, a decrease of 67.8% over the previous quarter.
For a complete picture of ARV-766s valuation, buy the drugs risk-adjusted NPV model (rNPV) here.
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