Avadomide hydrochloride is under clinical development by Bristol-Myers Squibb and currently in the Phase I and Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Avadomide hydrochloride’s likelihood of approval (LoA) and phase transition for Hepatocellular Carcinoma took place on 08 Jun 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Avadomide hydrochloride Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Avadomide hydrochloride overview

CC-122 is under development for the treatment of advanced solid tumors including non-Hodgkin's lymphoma, relapsed/refractory multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma, small lymphocytic lymphoma, diffuse large B cell lymphoma, indolent lymphoma, hepatocellular carcinoma, primary glioblastoma multiforme, metastatic melanoma and gliosarcoma. It is also under development in combination with nivolumab for the treatment of hepatocellular carcinoma who have progressed after or were intolerant to no more than 2 previous systemic therapies for unresectable HCC or are naive to systemic therapy. The drug candidate is administered orally in the form of the capsule. It targets CRBN (cereblon). The drug candidate is a non-phthalimide analog of the immunomodulatory drugs such as thalidomide.

Bristol-Myers Squibb overview

Bristol-Myers Squibb (BMS) is a specialty biopharmaceutical company that is engaged in discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, cardiovascular, immunology and fibrotic therapeutic projects. The company offers its products across the world to wholesalers, retail pharmacies, hospitals, medical professionals and government entities. BMS provides its products in the US, Europe, and Japan. The company conducts research to focus on the discovery and development of novel medicines that address serious diseases in areas of significant unmet medical need. BMS is headquartered in New York City, New York, the US.

Quick View Avadomide hydrochloride LOA Data

Report Segments
  • Innovator
Drug Name
  • Avadomide hydrochloride
Administration Pathway
  • Oral
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.