Bintrafusp alfa is under clinical development by Merck and currently in the Phase I, Phase II and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Bintrafusp alfa’s likelihood of approval (LoA) and phase transition for Soft Tissue Sarcoma took place on 14 Dec 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Bintrafusp alfa Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Bintrafusp alfa overview

Bintrafusp alfa is under development for the treatment of  metastatic or locally advanced urothelial cancer, metastatic castration sensitive and castration resistant prostate cancer (mCSPC and mCRPC) , recurrent and metastatic olfactory neuroblastoma, triple negative breast cancer, recurrent and metastatic (R/M) non-keratinizing nasopharyngeal carcinoma (NPC), epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, metastatic pancreatic ductal adenocarcinoma (PDAC), metastatic urothelial carcinoma, metastatic or locally advanced solid tumors including castration-resistant prostate cancer and HPV associated tumors, melanoma, pancreatic cancer, glioblastoma multiforme, squamous cell carcinoma of the head and neck, recurrent respiratory papillomatosis, biliary tract cancer, oropharyngeal cancer, metastatic triple negative breast cancer, HER2 positive breast cancer, small cell lung cancer, squamous cell rectal cancer, vulvar cancer, anal cancer, vaginal cancer, penile cancer, neuroendocrine cancer, kaposi sarcoma, soft tissue sarcoma, colorectal cancer, non-small cell lung cancer, cervical cancer, metastatic non-prostate genitourinary malignancies including bladder cancer, kidney cancer, genital cancer, urinary tract cancer, thymoma and thymic carcinoma. It is a bifunctional fusion protein. It is administered through intravenous route. It is a new biological entity. It acts by targeting PD-L1 and TGF-Beta. It was also under development for the treatment of metastatic pancreatic adenocarcinoma, gastric cancer, esophageal squamous cell carcinoma, hepatocellular carcinoma.

Merck overview

Merck, a subsidiary of E. Merck KG, is a science and technology company. It discovers, develops and manufactures prescription drugs to treat cancer, multiple sclerosis and infertility; and develops liquid crystal mixtures, organic light-emitting diode (OLED) materials, cosmetic active ingredients, pigments for coatings, and high-tech materials. Merck also provides a wide range of products including lab water systems, gene editing tools, cell lines, antibodies and end-to-end systems. The company serves healthcare, performance materials, and life sciences markets. It has presence in Europe, North America, Asia-Pacific, Latin America and Middle East and Africa. Merck is headquartered in Darmstadt, Hesse, Germany.

Quick View Bintrafusp alfa LOA Data

Report Segments
  • Innovator
Drug Name
  • Bintrafusp alfa
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Infectious Disease
  • Oncology
Key Developers
  • Sponsor Company: Merck
  • Originator: EMD Serono
Highest Development Stage
  • Phase III

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.