BION-1301 is a monoclonal antibody commercialized by Chinook Therapeutics, with a leading Phase II program in IgA Nephropathy (Berger’s Disease). According to Globaldata, it is involved in 4 clinical trials, of which 1 was completed, 1 is ongoing, 1 is planned, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of BION-1301’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.

The revenue for BION-1301 is expected to reach an annual total of $13 mn by 2038 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.

BION-1301 Overview

BION-1301 is under development for the treatment of IgA nephropathy. It comprises of humanized IgG4 monoclonal antibody. The drug candidate targets APRIL-dependent survival in B-cell malignancies. The drug candidate is developed based on B-select antibody platform (B-select) technology. It is administered by intravenous and subcutaneous route. It was also under development for the treatment of  B-cell chronic lymphocytic lymphoma, colorectal cancer and relapsed or refractory multiple myeloma.

Chinook Therapeutics Overview

Chinook Therapeutics, Inc (Chinook)., formerly Aduro BioTech Inc is a clinical-stage immunotherapy company that discovers, develops and commercializes therapies for the treatment of cancer. The company develops product candidates using proprietary technology platforms such as live, attenuated, double-deleted listeria, sting pathway activators; and B-select monoclonal antibodies to create immunotherapies for the treatment of cancers, infectious and autoimmune diseases. Its products are under development and are intended for the treatment of variety of cancers, including metastatic colorectal, multiple myeloma cancers, as well as other solid tumors and lymphomas. The company collaborates with various pharmaceutical companies to expand its products, and technology platforms. It has an operational presence in The Netherlands. Chinook is headquartered in Berkeley, California, the US.

The company reported revenues of (US Dollars) US$51.6 million for the fiscal year ended December 2021 (FY2021), compared to a revenue of US$0.8 million in FY2020. The operating loss of the company was US$99 million in FY2021, compared to an operating loss of US$83.9 million in FY2020. The net loss of the company was US$102.9 million in FY2021, compared to a net loss of US$81.6 million in FY2020. The company reported revenues of US$2.5 million for the third quarter ended September 2022, compared to a revenue of US$0.4 million the previous quarter.

For a complete picture of BION-1301’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.