Bisantrene hydrochloride is under clinical development by Race Oncology and currently in the Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Bisantrene hydrochloride’s likelihood of approval (LoA) and phase transition for Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia) took place on 13 Oct 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway and decreased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Bisantrene hydrochloride Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Bisantrene hydrochloride overview

Bisantrene hydrochloride (UPI-928) is under development for the treatment of adult and pediatric relapsed and refractory acute myelogenous leukemia, permanent heart damage caused by the chemotherapeutic anthracycline doxorubicin, myelodysplastic syndrome, CMML, breast cancer, ovarian cancer. The drug candidate is a small molecule anthracene derivative. It acts by targeting FTO. It is administered through intravenous route.

Race Oncology overview

Race Oncology, formerly Coronado Resources, discovers and develops novel RNA (ribonucleic acid) directed drugs to treat cancer. The company is investigating Zantrene, a potent small molecule inhibitor of fat mass and obesity associated (FTO) protein for relapsed and refractory acute myeloid leukemia (r/r AML), extramedullary disease (EMD) AML, myelodysplastic syndrome (MDS), and breast cancer. It is also evaluating Zantrene against solid tumors, melanoma, clear cell renal cell carcinoma, and lung cancer. The company’s product candidate acts as an anthracycline-like chemotherapeutic causing less cardiotoxicity (heart damage) in cancer patients. Race Oncology is headquartered in Sydney, New South Wales, Australia.

Quick View Bisantrene hydrochloride LOA Data

Report Segments
  • Innovator
Drug Name
  • Bisantrene hydrochloride
Administration Pathway
  • Intravenous
Therapeutic Areas
  • Oncology
  • Toxicology
Key Developers
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.