Bomedemstat tosylate is a small molecule commercialized by Merck, with a leading Phase II program in Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF). According to Globaldata, it is involved in 12 clinical trials, of which 4 were completed, 6 are ongoing, and 2 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Bomedemstat tosylate’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Bomedemstat tosylate is expected to reach an annual total of $20 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Bomedemstat tosylate Overview
IMG-7289 is under development for the treatment of acute myelogenous leukemia (AML), polycythemia vera, essential thrombocythemia, myelodysplastic syndrome (MDS), myelofibrosis including post-polycythemia vera myelofibrosis (PPV-MF), post-essential thrombocythemia myelofibrosis (PET-MF), primary myelofibrosis and new chemical entities for hemoglobinopathies (hemoglobin deficiencies) and solid tumors (other malignances). It is administered through oral route. The drug candidate acts by targeting lysine specific demethylase 1 (LSD-1 or KDM1A).
Merck is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines, and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.
The company reported revenues of (US Dollars) US$59,283 million for the fiscal year ended December 2022 (FY2022), an increase of 21.7% over FY2021. In FY2022, the company’s operating margin was 30.3%, compared to an operating margin of 25.7% in FY2021. In FY2022, the company recorded a net margin of 24.5%, compared to a net margin of 26.8% in FY2021. The company reported revenues of US$14,487 million for the first quarter ended March 2023, an increase of 4.8% over the previous quarter.
For a complete picture of Bomedemstat tosylate’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.