BPX-401 is under clinical development by Bellicum Pharmaceuticals and currently in the Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect BPX-401’s likelihood of approval (LoA) and phase transition for Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia) took place on 11 Mar 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

In addition, the same event on 11 Mar 2022 increased BPX-401’s LoA and PTSR for Non-Hodgkin Lymphoma.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their BPX-401 Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

BPX-401 overview

BPX-401 is under development for the treatment of adult and pediatric acute lymphocytic leukemia and certain non-Hodgkin’s lymphomas. The therapy is composed of CAR T cells transduced with a retroviral vector to target CD19. CaspaCIDe technology consists of an inducible Caspase-9-based cell safety switch, and the small molecule activator, AP1903. It functions as a regulated switch to enhance the activity of the T cells. It was also under development for chronic lymphocytic leukemia

Bellicum Pharmaceuticals overview

Bellicum Pharmaceuticals, Inc. (Bellicum) is a clinical stage biopharmaceutical company, that develops cellular immunotherapies for the treatment of cancer. The company develops its product candidates through its chemical induction of dimerization technology platforms in the areas of cellular immunotherapy including hematopoietic stem cell transplantation, CAR T cell therapy and TCR cell therapies. Bellicum’s lead pipeline candidate includes BPX-501, an adjunct T cell therapy intended for the treatment of leukemias, lymphomas and genetic blood diseases. The company also develops pipeline products for the treatment of solid tumors, hematological cancers and others. Bellicum is headquartered in Houston, Texas, the US.

Quick View BPX-401 LOA Data

Report Segments
  • Innovator
Drug Name
  • BPX-401
Administration Pathway
Therapeutic Areas
  • Oncology
Key Developers
  • Sponsor Company: Bellicum Pharmaceuticals
  • Originator: Bellicum Pharmaceuticals
Highest Development Stage
  • Phase II

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.