Buntanetap is a small molecule commercialized by Annovis Bio, with a leading Phase III program in Parkinson’s Disease. According to Globaldata, it is involved in 15 clinical trials, of which 7 were completed, 5 are ongoing, 2 are planned, and 1 was terminated. GlobalData uses proprietary data and analytics to provide a complete picture of Buntanetap’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Buntanetap is expected to reach an annual total of $238 mn by 2035 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Buntanetap (ANVS-401 (Posiphen)) is under development for the treatment of Alzheimer's disease, Parkinson's disease, Alzheimer's disease in Down syndrome , frontotemporal dementia (FTD), chronic traumatic encephalopathy (CTE) and Lewy body dementia. The drug candidate is the enantiomer of phenserine. It is administered through oral route. It acts by targeting amyloid precursor protein (APP), tau and alpha-synuclein.
It was also under development for the treatment of Huntington’s disease and traumatic brain injury.
Annovis Bio Overview
Annovis Bio is a clinical-stage drug platform company that carries out the development of novel drugs for the treatment of various diseases. The company’s pipeline products include buntanetap, to treat parkinson’s disease (PD), alzheimer’s disease (AD), and other chronic neurodegenerative diseases; ANVS405, to treat traumatic brain injury (TBI) and stroke; ANVS301, to treat advanced alzheimer’s disease. It provides drug candidates in oral and injectable forms. Annovis Bio also carries out preclinical animal studies and clinical trials. The company collaborates with contractor laboratories, independent contractors and contract research organizations. Annovis Bio is headquartered in Berwyn, Pennsylvania, the US.
The operating loss of the company was US$25.5 million in FY2022, compared to an operating loss of US$14.5 million in FY2021. The net loss of the company was US$25.3 million in FY2022, compared to a net loss of US$14.5 million in FY2021.
For a complete picture of Buntanetap’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.