Capivasertib is under clinical development by AstraZeneca and currently in the Phase I, Phase II and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Capivasertib’s likelihood of approval (LoA) and phase transition for Metastatic Breast Cancer took place on 31 Oct 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Capivasertib Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Capivasertib overview

Capivasertib (AZD-5363) is under development for the treatment of relapsed or refractory (R/R) B-cell non-Hodgkin's lymphomas including follicular lymphoma (FL), marginal zone lymphoma (MZL) and mantle cell lymphoma (MCL), relapsed/refractory B-cell non-Hodgkin's lymphoma, advanced refractory lymphoma and multiple myeloma, diffuse large B cell lymphoma, solid tumors including metastatic triple negative breast cancer, advanced (inoperable) or metastatic HR+/HER2− breast cancer, HER2 positive breast cancer, hormone refractory castration resistant prostate cancer, metastatic hormone-sensitive prostate cancer, adenocarcinoma of prostate cancer, recurrent endometrial cancer, non-small cell lung cancer, ovarian cancer, primary peritoneal cancer and fallopian tube cancer. The drug candidate is administered through oral route as a tablet. It is a pyrrolopyrimidine-derived compound that targets all isoforms of AKT (protein kinase B). It was also under development for cervical cancer.

AstraZeneca overview

AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The COVID-19 Vaccine AstraZeneca has been approved for conditional marketing or emergency use. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.

Quick View Capivasertib LOA Data

Report Segments
  • Innovator
Drug Name
  • Capivasertib
Administration Pathway
  • Oral
Therapeutic Areas
  • Oncology
Key Developers
Highest Development Stage
  • Phase III

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.