Catequentinib hydrochloride is under clinical development by Advenchen Laboratories and currently in Phase II for Solid Tumor. According to GlobalData, Phase II drugs for Solid Tumor have a 10% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Catequentinib hydrochloride’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Catequentinib hydrochloride overview
Catequentinib (AL-3818) is under development for the treatment of advanced or metastatic differentiated thyroid cancer, metastatic urothelial carcinoma of the bladder cancer, urethral cancer, ureter cancer, renal pelvis cancer, non clear cell renal cell carcinoma, oropharyngeal cancer, hypopharyngeal cancer, laryngeal cancer, neuroblastoma, recurrent or metastatic cervical cancer, recurrent high-grade glioma, head and neck squamous cell carcinoma or non-squamous cell carcinoma, recurrent glioblastoma, melanoma, metastatic urothelial carcinoma, gastrointestinal pancreatic neuroendocrine tumor, metastatic advanced or recurrent soft tissue sarcomas, non-small cell lung cancer, small cell lung cancer, pancreatic cancer, ovarian cancer, metastatic ovarian cancer and gallbladder cancer, soft tissue sarcoma including synovial sarcoma, leiomyosarcoma, angiosarcoma, liposarcoma, alveolar soft part sarcoma, undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma, adipocytic tumors, fibrosarcoma, clear cell sarcoma, epithelioid sarcoma, gastric cancer including gastroesophageal junction adenocarcinoma, advanced medullary thyroid carcinoma, metastatic colorectal cancer, advanced renal cell carcinoma, esophageal squamous cell carcinoma, recurrent/metastatic nasopharyngeal carcinoma, ovarian cancer, small-cell lung cancer, metastatic hepatocellular carcinoma, undifferentiated carcinoma urothelial, non-squamous non-small cell lung cancer, peripheral T-cell lymphomas (PTCL) including non-specific peripheral T-cell lymphoma, angioimmunoblastic T-cell lymphoma (AITL), anaplastic large cell lymphoma (ALCL), enteropathy related T-cell lymphoma (EATL), monomorphic epithelial T-cell lymphoma (meitl), intranodal and extranodal Peripheral T-cell lymphoma (PTCL, TFH), follicular T-cell lymphoma (FTCL), NK / T-cell lymphoma, primary cutaneous T-cell lymphoma, HER2- breast cancer and unclassified peripheral T-cell lymphoma. It acts by targeting VEGFR2, VEGFR3, PDGFR beta and c-Kit. It was also under development for the treatment of colon cancer, squamous cell carcinoma, serous adenocarcinoma, clear cell adenocarcinoma, transitional cell carcinoma, peritoneal cancer, fallopian tube cancer, mixed epithelial carcinoma, mucinous adenocarcinoma, and cervical cancer.
It was also under development for solid tumors, refractory or relapsed diffuse large B-cell lymphoma, osteosarcoma, chondrosarcoma, ewing sarcoma, primitive neuroectodermal tumor, giant cell tumor of bone undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma, endometrial cancer, esophageal cancer, gallbladder cancer, melanoma, metastatic pancreatic cancer, liver cancer, gastrointestinal stromal tumors, cholangiocarcinoma, oral cavity (mouth) cancer, neuroendocrine gastroenteropancreatic tumors (GEP-NET), pleomorphic liposarcoma, gastrointestinal tumor, thymic carcinoma, recurrent/metastasis pleural mesothelioma, squamous non-small cell lung cancer.
For a complete picture of Catequentinib hydrochloride’s drug-specific PTSR and LoA scores, buy the report here.