CBL-0137 is under clinical development by Incuron and currently in the Phase I and Phase II in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect CBL-0137’s likelihood of approval (LoA) and phase transition for Melanoma took place on 07 Dec 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway and decreased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their CBL-0137 Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

CBL-0137 overview

CBL-0137 (CBLC-137) is under development for the treatment of melanoma (second line therapy), sarcoma (second line therapy) and resistant or refractory advanced solid cancers, osteosarcoma and pediatric diffuse intrinsic pontine glioma. It is administered through oral, intraarterial, and intravenous routes. The drug candidate is a carbazole-derived compound. It is developed based on Curaxin technology.

It was also under development for the treatment of pancreatic ductal adenocarcinoma, colon adenocarcinoma, renal cell carcinoma, human non-small cell lung cancer, mammary gland adenocarcinoma, pancreatic cancer, head and neck cancer, prostate cancer, melanoma, glioblastoma, neuroblastoma, glioblastoma multiforme (second line therapy), hematological malignancies like diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, Hodgkin lymphoma (B -cell Hodgkin lymphoma), chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (all, acute lymphoblastic leukemia), acute myelocytic leukemia (aml, acute myeloblastic leukemia), multiple myeloma (Kahler disease), B -cell non-Hodgkin lymphoma and human African trypanosomiasis.

Incuron overview

Incuron is a biotechnology company developing anticancer therapies. Incuron is headquartered in Moscow, Russia.

Quick View CBL-0137 LOA Data

Report Segments
  • Innovator
Drug Name
  • CBL-0137
Administration Pathway
  • Intraarterial
  • Intravenous
  • Oral
Therapeutic Areas
  • Infectious Disease
  • Oncology
Key Developers
  • Sponsor Company: Incuron
  • Originator: Statera Biopharma
Highest Development Stage
  • Phase II

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.