CC-90001 is a Small Molecule owned by Bristol-Myers Squibb, and is involved in 2 clinical trials, of which 1 was completed, and 1 is ongoing.

CC-90001 is a JNK1 inhibitor. Protein kinases such as JNKs regulate cell-cycle progression, transcription, translation, protein sorting, and cell adhesion events that are critical to the inflammatory process. JNK pathway is stimulated by cell surface receptor activation or G-protein mediated signaling. The activated JNKs translocate to the nucleus and phosphorylate transcription factors thereby inducing gene expression. The JNK pathways regulate the activity and expression of key inflammatory mediators such as cytokines and proteases.

The revenue for CC-90001 is expected to reach a total of $255m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the CC-90001 NPV Report.

CC-90001 was originated by Celgene and is currently owned by Bristol-Myers Squibb.

CC-90001 Overview

CC-90001 is under development for the treatment of idiopathic pulmonary fibrosis (IPF), solid tumors including non-small cell lung cancer (NSCLC), metastatic triple negative breast cancer (mTNBC), squamous cell carcinoma of head and neck (SCCHN), pancreatic adenocarcinoma (PAAD), renal cell carcinoma (RCC), microsatellite-stable colorectal carcinoma (MSS CRC) and sarcoma. The drug candidate is administered orally in the form of film-coated tablet. CC-90001 is a second generation JNK1 inhibitor. It was also under development for liver fibrosis.

It was under development for the treatment of non-alcoholic steatohepatitis (NASH) with stage 3 or stage 4 liver fibrosis.

Bristol-Myers Squibb Overview

Bristol-Myers Squibb (BMS) is a specialty biopharmaceutical company that is engaged in discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, cardiovascular, immunology and fibrotic therapeutic projects. The company offers its products across the world to wholesalers, retail pharmacies, hospitals, medical professionals and government entities. BMS provides its products in the US, Europe, and Japan. The company conducts research to focus on the discovery and development of novel medicines that address serious diseases in areas of significant unmet medical need. BMS is headquartered in New York City, New York, the US.

The company reported revenues of (US Dollars) US$46,385 million for the fiscal year ended December 2021 (FY2021), an increase of 9.1% over FY2020. The operating profit of the company was US$8,615 million in FY2021, compared to an operating loss of US$6,847 million in FY2020. The net profit of the company was US$6,994 million in FY2021, compared to a net loss of US$9,015 million in FY2020. The company reported revenues of US$11,218 million for the third quarter ended September 2022, a decrease of 5.6% over the previous quarter.

Quick View – CC-90001

Report Segments
  • Innovator
Drug Name
  • CC-90001
Administration Pathway
  • Oral
Therapeutic Areas
  • Gastrointestinal
  • Oncology
  • Respiratory
Key Companies
Highest Development Stage
  • Phase II


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.