CD19 CAR-T Cells is under clinical development by Shanghai YaKe Biotechnology and currently in Phase II for Diffuse Large B-Cell Lymphoma. According to GlobalData, Phase II drugs for Diffuse Large B-Cell Lymphoma have a 30% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how CD19 CAR-T Cells’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

CD19 CAR-T Cells overview

Gene therapy is under development for the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia or B-cell non-Hodgkin's lymphomas including diffuse large b-cell lymphoma, chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), high grade B-cell lymphoma (HGBCL), primary mediastinal B-cell lymphoma (PMBCL) and follicular lymphoma. The therapeutic candidate constitutes autologous T cells expressing CD19 chimeric antigen receptors. It acts by targeting CD19 expressing cancer cells. It is administered through intravenous route. It was also under development for the treatment of minimal residual disease (MRD) in B-cell Malignancies (B-cell leukemia and unspecified B-cell lymphomas). 

For a complete picture of CD19 CAR-T Cells’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.