Cebranopadol is under clinical development by Tris Pharma and currently in the Phase I and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Cebranopadol’s likelihood of approval (LoA) and phase transition for Substance (Drug) Abuse took place on 15 Dec 2022, which decreased the likelihood that the drug progresses to the next phase in its clinical pathway and decreased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Cebranopadol Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Cebranopadol overview

Cebranopadol (GRT-6005) is under development for the treatment of cancer pain and substance drug abuse . It is an orally administered analgesic agent that exhibits a potent agonist activity on opioid receptor like -1 (ORL1) and mu opioid receptor.

It was also under development for the treatment of chronic nociceptive pain and chronic moderate to severe pain related to cancer, chronic pain due to diabetic peripheral neuropathy, post-operative pain in hallux valgus (Bunion), chronic pain due to knee osteoarthritis (OA), addiction and chronic low back pain

Tris Pharma overview

Tris Pharma discovers, develops and commercializes over-the-counter and generic products. The company’s pipeline product candidates include TRN-110, TRN-124, TRN-125, TRN-167, TRN-123, TRN-152, TRN-148, TRN-219, TRN-213 and TRN-226. Its generic products include colesevelam, dexmethylphenidate, dextroamphetamine, doxycycline Hyclate, doxycycline hyclate, droxidopa, febuxostat, hydrocodone, hydrocodone polistirex, lacosamide, methylphenidate, morphine sulfate and paliperidone ER. Tris Pharma is headquartered in South Brunswick, New Jersey, the US.

Quick View Cebranopadol LOA Data

Report Segments
  • Innovator
Drug Name
  • Cebranopadol
Administration Pathway
  • Oral
Therapeutic Areas
  • Central Nervous System
Key Developers
Highest Development Stage
  • Phase III

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.