Cenerimod is a Small Molecule owned by Idorsia Pharmaceutical, and is involved in 10 clinical trials, of which 6 were completed, and 4 are ongoing.

Cenerimod (ACT-334441) acts as sphingosine-1-phosphate receptor 1 (S1P1) agonist. In the presence of a selective S1P1 receptor agonist, lymphocytes lose their ability to sense S1P concentration gradients. As a consequence, selective S1P1 receptor agonist block lymphocyte migration out of lymphoid tissue into the lymphatic and blood circulation, thereby reducing peripheral lymphocyte counts and preventing lymphocyte recruitment to sites of inflammation.

The revenue for Cenerimod is expected to reach a total of $909m through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Cenerimod NPV Report.

Cenerimod was originated by Actelion Pharmaceuticals and is currently owned by Idorsia Pharmaceutical.

Cenerimod Overview

Cenerimod (ACT-334441) is under development for the treatment of systemic lupus erythematosus. It is a small molecule administered oral route in the form of capsule. It acts by targeting sphingosine-1-phosphate receptor 1 (S1P1). It was also under development for the treatment of sicca syndrome (sjogren).

Idorsia Pharmaceutical Overview

Idorsia Pharmaceutical (Idorsia) is a biopharmaceutical company that discovers, develops, and commercializes small molecules to treat the central nervous system and cardiovascular and immunological disorders. It is investigating daridorexant against insomnia; aprocitentan for the treatment of resistant hypertension; clazosentan to treat cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage; and L-lucerastat compound targeting fabry disease. The company is also evaluating drugs against suspected acute myocardial infarction, systemic lupus erythematosus, Binge eating disorder, and rare lysosomal storage disorders. It works in collaboration with Janssen Biotech to develop and commercialize Aprocitentan drug candidates. Idorsia is headquartered in Allschwil, Switzerland.

The company reported revenues of (Swiss Francs) CHF35.4 million for the fiscal year ended December 2021 (FY2021), a decrease of 50.7% over FY2020. The operating loss of the company was CHF613 million in FY2021, compared to an operating loss of CHF410.6 million in FY2020. The net loss of the company was CHF634.6 million in FY2021, compared to a net loss of CHF444.8 million in FY2020. The company reported revenues of CHF21 million for the third quarter ended September 2022, an increase of 23.1% over the previous quarter.

Quick View – Cenerimod

Report Segments
  • Innovator
Drug Name
  • Cenerimod
Administration Pathway
  • Oral
Therapeutic Areas
  • Immunology
Key Companies
Highest Development Stage
  • Phase III

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.