Cenplacel-L is under clinical development by Celularity and currently in Phase II for Crohn’s Disease (Regional Enteritis). According to GlobalData, Phase II drugs for Crohn’s Disease (Regional Enteritis) have a 48% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Cenplacel-L’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Cenplacel-L overview
Cenplacel-L (PDA-001) is under development for the treatment of Crohn’s disease. It is administered through intravenous infusion. The therapeutic candidate comprised of human placenta-derived cells at a concentration of 7.5 cells/mL frozen in solution containing 5.5precent (W/V) Dextran-40, 10percent (W/V) human serum albumin (HSA), and 5 (V/V) dimethyl sulfoxide (DMSO). It was also under development for rheumatoid arthritis, multiple sclerosis, ischemic stroke and pulmonary sarcoidosis.
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Celularity overview
Celularity is a biotechnology company that develops and commercializes therapeutics derived from the placenta for autoimmune and degenerative diseases, immuno-oncology, and functional regeneration. The company’s pre-clinical and clinical assets include CAR-T cell receptor and CAR-NK products; and functional regeneration products for wounds, burns, orthopedic, and other surgical indications. It also provides cord blood and placental blood and tissue biosourcing options. Celularity harnesses allogeneic placental cell platform to develop its product portfolio. The company’s products find application in the treatment of acute myeloid leukemia, crohn’s disease, diabetic peripheral neuropathy, and oral and aesthetic tissue repair among others. Celularity is headquartered in Warren, New Jersey, the US.
For a complete picture of Cenplacel-L’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
