CKD-516 is under clinical development by Chong Kun Dang Pharmaceutical and currently in Phase I for Solid Tumor. According to GlobalData, Phase I drugs for Solid Tumor have a 54% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how CKD-516’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

CKD-516 overview

CKD-516 (NOV-120401) is under development for the treatment of advanced solid tumors and colorectal cancer, pancreatic cancer, cholangiocarcinoma, stomach cancer and esophageal cancer. It is a new chemical entity (NCE) which is administered intravenously and orally. The drug candidate is a benzophenone derivative and water soluble valine prodrug of the tubulin binding agent S516. It acts as vascular disrupting agent (VDA), based on tubulin polymerization inhibition.

Chong Kun Dang Pharmaceutical overview

Chong Kun Dang Pharmaceutical (CKD Pharma), an affiliate of Chong Kun Dang, manufactures, distributes, imports and exports prescription drugs, OTC drugs, health supplements and consumer health products. The company works following therapeutic areas such as oncology, neurology and immunology and others. Its product portfolio includes prescription products for the entire segment and therapeutic classes; vitamins; shampoos; hair colors; aerosols; mat vaporizers and mosquito coils; and others. The company’s Chong Kun Dang Research Institute is characterized by three independent laboratories, namely, The New Drug Discovery Labs; The Technology Development Labs; and the Bio Research Labs. It has manufacturing facility in Cheonan City, South Korea. CKD Pharma is headquartered in Seoul, South Korea.

For a complete picture of CKD-516’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.