Cotadutide is a peptide commercialized by AstraZeneca, with a leading Phase III program in Non-Alcoholic Steatohepatitis (NASH). According to Globaldata, it is involved in 16 clinical trials, of which 13 were completed, and 3 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Cotadutide’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Cotadutide is expected to reach an annual total of $23 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Cotadutide (MEDI-0382) is under development for the treatment of type II diabetes, diabetic kidney disease (diabetic nephropathy) and non-alcoholic steatohepatitis (NASH). The drug candidate is administered through subcutaneous route as a solution. It is a peptide which acts by targeting glucagon like peptide-1 (GLP-1R) receptor and glucagon receptor. It is a new molecular entity (NME). It was under development for obesity.
AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The COVID-19 Vaccine AstraZeneca has been approved for conditional marketing or emergency use. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.
The company reported revenues of (US Dollars) US$44,351 million for the fiscal year ended December 2022 (FY2022), an increase of 18.5% over FY2021. The operating profit of the company was US$3,757 million in FY2022, compared to an operating profit of US$1,056 million in FY2021. The net profit of the company was US$3,288 million in FY2022, compared to a net profit of US$112 million in FY2021.
For a complete picture of Cotadutide’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.