Danvatirsen sodium is under clinical development by AstraZeneca and currently in Phase II for Oropharyngeal Cancer. According to GlobalData, Phase II drugs for Oropharyngeal Cancer have a 50% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Danvatirsen sodium’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Danvatirsen sodium overview

Danvatirsen sodium (IONIS-STAT3) is under development for the treatment of recurrent and metastatic head and neck cancer squamous cell carcinoma, oropharyngeal cancer, oral cavity cancer, hypopharyngeal cancer, laryngeal cancer, advanced solid malignancies, pancreatic cancer, non-small cell lung cancer, colorectal cancer. It is administered through intravenous route. The drug candidate is a 16 oligonucleotide antisense molecule (ASO) targeting the 3' untranslated part of signal transducer and activator of transcription 3 (STAT3). It is based on FLAME discovery engine. It was also under development for the treatment of metastatic hepatocellular carcinoma, gastrointestinal cancer, ovarian cancer, malignant ascites and diffuse large B-Cell lymphoma. It is being developed based on FLAME (Flamingo Long non-coding RNA (LncRNA) Antisense Mining Engine) technology platform.

AstraZeneca overview

AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly- owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.

For a complete picture of Danvatirsen sodium’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 2 September 2023

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.