DM-199 is under clinical development by DiaMedica Therapeutics and currently in Phase II for Chronic Kidney Disease (Chronic Renal Failure). According to GlobalData, Phase II drugs for Chronic Kidney Disease (Chronic Renal Failure) have a 49% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how DM-199’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

DM-199 overview

DM-199 is under development for the treatment of diabetic nephropathy (diabetic kidney disease), other metabolic diseases, chronic kidney diseases in patients with type-1 diabetes and vascular dementia, IgA nephropathy. The drug candidate is administered through subcutaneous and intravenous route. DM-199 is a recombinant human tissue kallikrein-1 protein known as rhKLK-1.

The drug candidate was also under development for Alzheimer's disease, acute ischemic stroke, rheumatoid arthritis, type 2 diabetes, type 1 diabetes, acute kidney injury and Alport syndrome.

DiaMedica Therapeutics overview

DiaMedica Therapeutics (DiaMedica), formerly DiaMedica, is a biopharmaceutical company. It develops innovative medicines for the treatment neurological and kidney diseases. Its lead product candidate DM-199, is a human recombinant protein that treats diabetes type 1 and type 2, and associated complications including diabetic kidney disease and alport syndrome; and DM300 for treating acute pancreatitis. DiaMedica’s DM199 is also used for the treatment of diabetic nephropathy and post-insult treatment from acute ischemic stroke (AIS). The company discovers and develops novel therapies for kidney dysfunction and metabolic disorders. The company also provides clinical trial services. DiaMedica is headquartered in Minneapolis, Minnesota, the US.

For a complete picture of DM-199’s drug-specific PTSR and LoA scores, buy the report here.


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.