Ebola Zaire vaccine is a Live Attenuated Vaccine owned by Merck & Co, and is involved in 19 clinical trials, of which 17 were completed, and 2 are ongoing.

V-920 (BPSC-1001) elicits antiviral properties. Vaccine contains inactivated and weakened form of the virus glycoprotein that mimics the natural infection and stimulates a range of immune responses to recognize and destroy the pathogens when encountered. The vaccine candidate may be effective in the prevention of infections by inducing strong immunity against infections.

The revenue for Ebola Zaire vaccine is expected to reach a total of $1.9bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Ebola Zaire vaccine NPV Report.

Ebola Zaire vaccine was originated by Public Health Agency of Canada and is currently owned by Merck & Co.

Ebola Zaire vaccine Overview

Ebola Zaire vaccine (Ervebo) is a live attenuated, recombinant viral vaccine. It consists of a live attenuated recombinant Vesicular Stomatitis Virus (rVSV) (strain indiana) with a deletion of the VSV envelope glycoprotein replaced with the Zaire Ebolavirus (ZEBOV) (strain kikwit-1995) surface glycoprotein. It is formulated as suspension for intramuscular route of administration. Ervebo is indicated for active immunization of individuals 18 years of age or older to protect against Ebola virus disease and for the prevention of Ebola virus disease (EVD), caused by Zaire ebolavirus in individuals 18 years of age and older.

The vaccine is under development for the prevention of Ebolavirus infection in sub-Saharan Africa.

Merck & Co Overview

Merck & Co (Merck) is a biopharmaceutical company focused on the discovery, development, manufacturing and marketing of prescription medicines, biologic therapies, vaccines and animal health products. It offers prescription products for therapy areas related to cardiovascular, cancer, immune disorders, infectious, respiratory and women’s diseases, and diabetes. The company provides animal health products such as vaccines, poultry products, livestock products and aquaculture products. Merck sells medicines to drug wholesalers, retailers, hospitals, government agencies and managed health care providers; and animal health products to veterinarians, distributors and animal producers. The company and its subsidiaries operate in the Americas, Europe, the Middle East, Africa, Asia Pacific, and Latin America. Merck is known as MSD outside the US and Canada and is headquartered in Kenilworth, New Jersey, the US.

The company reported revenues of (US Dollars) US$48,704 million for the fiscal year ended December 2021 (FY2021), an increase of 17.3% over FY2020. In FY2021, the company’s operating margin was 25.7%, compared to an operating margin of 12% in FY2020. In FY2021, the company recorded a net margin of 26.8%, compared to a net margin of 17% in FY2020. The company reported revenues of US$14,959 million for the third quarter ended September 2022, an increase of 2.5% over the previous quarter.

Quick View – Ebola Zaire vaccine

Report Segments
  • Innovator (NME)
Drug Name
  • Ebola Zaire vaccine
Administration Pathway
  • Intramuscular
Therapeutic Areas
  • Infectious Disease
Key Companies
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, potential applicable patients, drug margins, company expenses, and pricing estimates. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.

The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate rNPV, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA)and phase transition success rate(PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.