Encorafenib is under clinical development by Pfizer and currently in the Phase I, Phase II and Phase III in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Encorafenib’s likelihood of approval (LoA) and phase transition for Metastatic Brain Tumor took place on 13 Oct 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Encorafenib Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Encorafenib overview

Encorafenib (Braftovi) acts as anti-neoplastic agent. It is formulated as hard gelatin capsules for oral route of administration. Braftovi is indicated in combination with binimetinib, for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, as detected by an FDA-approved test and treatment of adult patients with metastatic colorectal cancer (CRC) with a BRAF V600E mutation.

Encorafenib (LGX-818) is under development for the treatment of melanoma and non-small cell lung cancer, metastatic thyroid cancerar, advanced BRAF mutant metastatic colorectal cancer and metastatic BRAF (gene) mutant melanoma, refractory and relapsed multiple myeloma. It was also under development for the treatment of non-small cell lung cancer, thyroid cancer, brain metastases and hematological malignancies.

Pfizer overview

Pfizer discovers, develops, manufactures and commercializes biopharmaceuticals. The company offers products to treat various conditions such as cardiovascular, metabolic and pain, cancer, inflammation, immune disorders and rare diseases. It also provides sterile injectable pharmaceuticals, biosimilars, active pharmaceutical ingredients (APIs) and contract manufacturing services. Pfizer sells its products through wholesalers, retailers, hospitals, clinics, government agencies and pharmacies. It has major manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US. The company provides its products in North America, South America, Asia-Pacific, Australia, Europe, Africa and the Middle East. Pfizer is headquartered in New York, the US.

Quick View Encorafenib LOA Data

Report Segments
  • Innovator (NME)
Drug Name
  • Encorafenib
Administration Pathway
  • Oral
Therapeutic Areas
  • Oncology
Key Developers
  • Sponsor Company: Pfizer
  • Originator: Novartis
Highest Development Stage
  • Marketed

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.