Etrasimod is under clinical development by Pfizer and currently in the Phase II, Phase III and Pre-Registration in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Etrasimod’s likelihood of approval (LoA) and phase transition for Atopic Dermatitis (Atopic Eczema) took place on 08 Nov 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Etrasimod Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Etrasimod overview

Etrasimod (APD-334) is under development for the treatment of moderately to severely active ulcerative colitis, Crohn's disease, atopic dermatitis, alopecia areta and Eosinophilic Esophagitis (EOE). The drug candidate is a next-generation small molecule and is administered through oral route. It acts by targeting S1P1, S1P4 and S1P5 receptors. It is developed based on GPCR-based drug discovery technology platform. It was also under development for autoimmune diseases such as multiple sclerosis, psoriasis, rheumatoid arthritis and dermatological extraintestinal manifestations (EIM) in patients with inflammatory bowel disease. It was also under development for pyoderma gangrenosum and primary biliary cirrhosis (cholangitis).

Pfizer overview

Pfizer discovers, develops, manufactures and commercializes biopharmaceuticals. The company offers products to treat various conditions such as cardiovascular, metabolic and pain, cancer, inflammation, immune disorders and rare diseases. It also provides sterile injectable pharmaceuticals, biosimilars, active pharmaceutical ingredients (APIs) and contract manufacturing services. Pfizer sells its products through wholesalers, retailers, hospitals, clinics, government agencies and pharmacies. It has major manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US. The company provides its products in North America, South America, Asia-Pacific, Australia, Europe, Africa and the Middle East. Pfizer is headquartered in New York, the US.

Quick View Etrasimod LOA Data

Report Segments
  • Innovator
Drug Name
  • Etrasimod
Administration Pathway
  • Oral
Therapeutic Areas
  • Central Nervous System
  • Dermatology
  • Gastrointestinal
  • Immunology
Key Developers
  • Sponsor Company: Pfizer
  • Originator: Arena Pharmaceuticals
Highest Development Stage
  • Pre-Registration

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.