Felezonexor is under clinical development by Stemline Therapeutics and currently in Phase I for Non-Small Cell Lung Cancer. According to GlobalData, Phase I drugs for Non-Small Cell Lung Cancer have an 80% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Felezonexor’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Felezonexor overview

Felezonexor (CBS-9106) was under development for the treatment of solid tumors including colorectal, gastrointestinal, breast, genitourinary cancers, non-small cell lung cancer. The drug candidate is a novel small molecule. It is administered orally. The drug candidate acts by targeting Exportin 1. CBS-9106 activates p53 and induces apoptosis. The drug candidate is developed based on the company's proprietary phenotype screening platform. It was also under development for neuroendocrine tumors.

It was under development for the treatment of multiple myeloma, prostate cancer and hematological tumors including acute lymphocytic leukemia.

Stemline Therapeutics overview

Stemline Therapeutics (Stemline), a subsidiary of A. Menarini Industrie Farmaceutiche Riunite Srl, is a clinical stage biopharmaceutical company that develops therapeutics to treat cancer stem cells. The company pipeline products include TAGRAXOFUSP, ELACESTRANT, SL-701, MEN1611, MEN1611, MEN1309, FELEZONEXOR and SL-901. Stemline products treat blastic plasmacytoid dendritic cell neoplasm (BPDCN), chronic myelomonocytic leukemia (CMML), myelofibrosis (MF), breast cancer, acute myeloid leukemia (AML), colorectal cancer (CRC) and solid tumors. It also carries out the development and commercialization of novel oncology therapeutics. The company has operations across Europe. Stemline is headquartered in New York, the US.

For a complete picture of Felezonexor’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.