Fruquintinib is under clinical development by Hutchison MediPharma and currently in the Phase I, Phase II and Pre-Registration in clinical pathway. The characteristics of the clinical trial as well as other attributes related to the drug, regulations, and company play a fundamental role in ensuring the likelihood of transition that the drug moves from its current development stage to next.

According to GlobalData, the latest event to affect Fruquintinib’s likelihood of approval (LoA) and phase transition for Endometrial Cancer took place on 17 Mar 2022, which increased the likelihood that the drug progresses to the next phase in its clinical pathway and increased the likelihood of final approval for this indication.

GlobalData uses proprietary data and analytics to provide a complete picture of this assessment in their Fruquintinib Likelihood of Approval (LoA) and Phase Transition Success Rate (PTSR) Report.

Fruquintinib overview

Fruquintinib (Elunate) is an anti-neoplastic agent. It is formulated as hard gelatin capsules for oral route of administration. Elunate is indicated for the treatment of metastatic colorectal cancer patients, who have failed at least two prior systemic antineoplastic therapies including fluoropyrimidine, oxaliplatin and irinotecan, with or without prior use of anti-vascular endothelial growth factor or anti-epidermal growth factor receptor therapies.

Fruquintinib (HMPL-013) is under development for the treatment of locally advanced rectal cancer, desmoplastic small round cell tumor, epithelioid hemangioendothelioma, solitary fibroma, angiosarcoma, soft tissue sarcoma, advanced or metastatic triple negative breast cancer, HER2 negative breast cancer, metastatic colorectal adenocarcinoma, metastatic renal cell carcinoma, metastatic biliary tract adenocarcinoma, advanced solid tumor including gastric cancer, gastroesophageal junction adenocarcinoma and advanced non squamous non small cell lung cancer, ovarian cancer, endometrial cancer, cervical cancer, breast cancer, advanced or recurrent/metastatic pancreatic adenocarcinoma and meningioma. It is administered orally. It was also under development for hepatocellular carcinoma and thymic cancer.

Hutchison MediPharma overview

Hutchison MediPharma (HMPL) carries out discovery, development and commercialization of therapeutics in oncology and autoimmune diseases. The company’s products include savolitinib, fruquintinib, sulfatinib, HMPL-523, epitinib, theliatinib, HMPL-453, HMPL-689 and HMPL-004. It develops drug discovery technologies in molecular and cell biology, high throughput screening, genomics and informatics to support research and development projects. HMPL’s research and development programs comprise gene-targeted and cell-based screening assays, ligand-dependent screening assays and signal transduction pathway screening assays. The company’s products serve in the fields of medicinal chemistry, pharmacology, oncology, cardiovascular and respiratory diseases, and antiviral treatments. It operates through its two offices in Pudong, China. HMPL is headquartered in Pudong, China.

Quick View Fruquintinib LOA Data

Report Segments
  • Innovator (NME)
Drug Name
  • Fruquintinib
Administration Pathway
  • Oral
Therapeutic Areas
  • Oncology
Key Developers
  • Sponsor Company: Hutchison MediPharma
  • Originator: Hutchison MediPharma
Highest Development Stage
  • Marketed


GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in its clinical pathway (PTSR), as well as how likely the drug will be approved (LoA). This is based on a proprietary algorithm built from the drugs’ sales forecast, regulatory milestones, cost forecasts, WACC rate and other proprietary data sources found on GlobalData’s Pharmaceutical Intelligence Center.