Fulvestrant is under clinical development by AstraZeneca and currently in Phase II for Leiomyosarcoma. According to GlobalData, Phase II drugs for Leiomyosarcoma have a 17% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Fulvestrant’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

Smarter leaders trust GlobalData

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Fulvestrant overview

Fulvestrant (Faslodex/Frexivo), a selective estrogen receptor degrader (SERD), acts as anti-estrogen agent. It is formulated as injection, solution for intramuscular route of administration. It is indicated for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It is indicated for the treatment for advanced breast cancer, with a distinct and different mode of action. Faslodex is also indicated in combination with palbociclib or in combination with abemaciclib for the treatment of women with hormone receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced or metastatic breast cancer (MBC) whose cancer has progressed after endocrine therapy, as monotherapy for expanded use in women with hormone-receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer, who have gone through menopause and have not received previous endocrine therapy.

Faslodex is under development for the treatment of ovarian cancer, peritoneal cancer, fallopian tube carcinoma, endometrial stromal sarcoma, uterine adenosarcoma, leiomyosarcoma, endometrial carcinoma, sex cord stromal tumors, serous ovarian cancer. It was also under development for the treatment of recocious puberty with McCune-Albright syndrome, recurrent or metastatic endometrial carcinoma, systemic lupus erythematosus, HER2 positive breast cancer, HER2 negative breast cancer, non-small cell lung cancer, and hormone refractory (castration resistant, androgen-independent) prostate cancer.

AstraZeneca overview

AstraZeneca is a biopharmaceutical company, which is focused on discovery, production and commercialization of a range of prescription drugs. It develops products related to therapy areas such as respiratory, cardiovascular, renal and metabolic diseases, cancer, autoimmune, infection and neurological diseases. The company’s product portfolio includes biologics, prescription pharmaceuticals and vaccines. AstraZeneca sells its products through wholly-owned local marketing companies, distributors and local representative offices. The company markets its products to primary care and specialty care physicians. The company operates in Europe, the Americas, Asia, Africa and Australasia. AstraZeneca is headquartered in Cambridge, Cambridgeshire, the UK.

For a complete picture of Fulvestrant’s drug-specific PTSR and LoA scores, buy the report here.

Data Insights

From

The gold standard of business intelligence.

Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.

GlobalData

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.