Gene Therapy to Target PD-L1 for Oncology is under clinical development by Marino Biotechnology and currently in Phase I for Pancreatic Cancer. According to GlobalData, Phase I drugs for Pancreatic Cancer have a 74% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Gene Therapy to Target PD-L1 for Oncology’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.

GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Gene Therapy to Target PD-L1 for Oncology overview

Gene therapy is under investigation for the treatment of recurrent glioblastoma multiforme, recurrent or metastatic malignant tumors including pancreatic cancer, kidney cancer, colorectal cancer, breast cancer, lung cancer and lymphoma. It is administered through intravenous infusion. The therapeutic candidate consists of CSR viral vector and is a chimeric switch receptor engineered T cells containing the extracellular domain of PD1 fused to the transmembrane and cytoplasmic domain of the costimulatory molecule CD28. It targets cells expressing programmed cell death 1 ligand 1 (PD L1).

For a complete picture of Gene Therapy to Target PD-L1 for Oncology’s drug-specific PTSR and LoA scores, buy the report here.

This content was updated on 10 June 2024

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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.