Glofitamab is under clinical development by F. Hoffmann-La Roche and currently in Phase II for Primary Mediastinal B-Cell Lymphoma. According to GlobalData, Phase II drugs for Primary Mediastinal B-Cell Lymphoma have an 82% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Glofitamab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Glofitamab (Columvi) is a bispecific monoclonal antibody, antineoplastic agent. It is formulated as solution concentrate for the intravenous route of administration. Columvi is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from follicular lymphoma (trFL), or primary mediastinal B-cell lymphoma (PMBCL), who have received two or more lines of systemic therapy and are ineligible to receive or cannot receive CAR-T cell therapy or have previously received CAR-T cell therapy.
Glofitamab is under development for the treatment of B-Cell non-Hodgkin lymphoma, high-grade B-cell lymphoma (HGBCL), marginal zone B-cell lymphoma, mantle cell lymphoma, primary mediastinal B-cell lymphoma, high-grade B-cell lymphoma, follicular lymphoma as a second line therapy and diffuse large B-cell lymphoma as a first line therapy(DLBCL). It is also under development for Burkitt lymphoma. The drug candidate is a T cell-dependent bi-specific antibody (CD20-CD3). It is administered through intravenous route.
For a complete picture of Glofitamab’s drug-specific PTSR and LoA scores, buy the report here.